Lecture 30 DNA Replication Slides

Lecture 30 DNA Replication Slides - DNA Replication and...

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Unformatted text preview: DNA Replication and Repair Chapter 16 6 th ed: pp 293 301 6 th ed: pp. 293-301 7 th ed: pp. 299-307 8 th ed: pp. 311-319 To learn well: Sum of DNA replication (Fig. 16.16, 7 th ed. Fig. 16.17, 8 th ed.) Watson & Cricks model for DNA replication for DNA replication 1. Complementary DNA strands temporarily separate separate Weak hydrogen bonds between bases are between bases are easy to break. 2. New nucleotides are inserted in turn, following base-pairing rules, using BOTH original strands as templates strands as templates. 3. Nucleotides are con- nected to make new nected to make new continuous strands Replication is sem - Replication is semi conservative ; each new molecule has 1 old, and 1 new strand. General name for any nucleotide: dNTP 1 4 2 Each sugar C has a 2 number (1-5) 5C: linked to phosphate 5 C: linked to phosphate 3C: linked to free OH Step 1. Correct dNTP base pairs with a base base pairs with a base in template Step 2. Phosphate of incoming dNTP is linked incoming dNTP is linked to -OH on the last sugar of the new strand sugar phos- phate Pyrophosphate (P-P) is released when the new phosphodiester bond phosphodiester bond is made. DNA polymerase BOTH checks that base pairing checks that base pairing is correct, and forms the bond to link the new nucleotide to the end of nucleotide to the end of the strand....
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This note was uploaded on 09/04/2009 for the course SBU 101 taught by Professor Debag during the Spring '09 term at SUNY Stony Brook.

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Lecture 30 DNA Replication Slides - DNA Replication and...

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