Lecture 33 Mutations and Operons Notes

Lecture 33 Mutations and Operons Notes - Part I Mutations...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
Part I: Mutations 6 th : 280-281; 322-323 7 th : 286; 328-330 8 th : 298; 344-346 Part II: Gene Reg - ulation In Bacteria 6 th : 347-349 7 th : 352-354 8 th : 351-353
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Mutation: uncorrected error in DNA sequence Mutations are heritable and MAY change the amino acid order in a protein. A mutation MAY change protein function or destroy function.
Background image of page 2
Types of mutation 1. Point mutation : single base change 2. Insertion or deletion : one or more bases added or left out 3. Large-scale changes in chromosome structure ex.: inversion, duplication
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Substitution :replacement of 1 nucleotide by another (BOTH strands) Error! Correct Replication Next replication Parental DNA
Background image of page 4
Silent mutation : a substitution that changes a codon to another that encodes the same amino acid ACA ; codes for threonine AC G ; also codes for threonine Silent mutation has NO EFFECT on amino acid sequence in protein
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Missense mutation : a point mutation that changes aa sequence CAC: histidine CA A : glutamine Missense mutation may have either a large or small effect on protein function - or no effect at all.
Background image of page 6
Sickle cell disease : caused by a missense mutation in the β -globin gene.
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Nonsense mutation : a point mutation that creates a stop codon. RESULT : premature termination & a shorter protein (usually defective).
Background image of page 8
: extra or missing nucleotides. Unless these occur in multiples of 3, they are frameshift mutations . Frameshift mutations:
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 10
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 42

Lecture 33 Mutations and Operons Notes - Part I Mutations...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online