Lecture%203%20080408

Lecture%203%20080408 - BILD 1 Lecture 2 April 3, 2008...

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BILD 1 Lecture 2 April 3, 2008 Macromolecules I
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Interesting Halloween Research: Vampires David Dolphin, Ph.D. is an organic chemist (and porphyrin chemist) at the University of British Columbia in Vancouver. He proposed in 1985 that people suffering from porphyria may be the vampires of folklore. Why? Porphyria is caused by defects in the heme biosythesis pathway Porphyria victims are sensitive to sunlight. Mild exposure can cause rashes, blisters, swelling, and disfigurement Heme intermediates accumulate in the nails, hair, and teeth, and cause them to turn brownish-red in color Porphyria sufferers must obtain heme from an outside source. Blood letting relieves symptoms. Porphyria is inherited and exacerbated in small gene pools (isolated populations)
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Interesting Halloween Research: Vampires
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Preview Macromolecules I: Polymers Carbohydrates Lipids Fats Phospholipids Steroids
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“Definition” of a polymer Monomers Polymers Condensation Hydrolysis Dehydration Polymer synthesis Polymer degradation
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Synthesis of Polymers HO H 1 2 3 HO HO H 1 2 3 4 H H 2 O Short polymer Unlinked monomer Longer polymer Dehydration removes a water molecule, forming a new bond REQUIRES Energy = ANABOLIC Monomers form larger molecules through condensation/dehydration reactions
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HO 1 2 3 H HO H 1 2 3 4 H 2 O H HO Hydrolysis adds a water molecule, breaking a bond The Breakdown of Polymers RELEASES Energy = CATABOLIC Polymers are broken down to monomers by hydrolysis
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The Diversity of Polymers Each class of polymer is formed from a specific set of monomers An immense variety of polymers can be built from a small set of monomers A polymer is “a substance composed of repeating structural units, or monomers, connected by covalent chemical bonds.”
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ACROMOLECULES I Four main classes of biological macromolecules:
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This note was uploaded on 09/05/2009 for the course BILD BILD1 taught by Professor Bever during the Spring '08 term at UCSD.

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Lecture%203%20080408 - BILD 1 Lecture 2 April 3, 2008...

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