Lecture%2020%20080605%20regulation

Lecture%2020%20080605%20regulation - BILD 1 Lecture 20...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: BILD 1 Lecture 20 6-5-2008 Eukaryotic Genome Gene Regulation Lecture Outline Eukaryotic genome packaging (i.e. chromatin) Eukaryotic gene regulation Chromatin Histone modification DNA methylation Transcription initiation Alternative splicing Many Levels of Eukaryotic Gene Regulation NUCLEUS CYTOPLASM CHROMATIN TRANSCRIPTION RNA PROCESSING RNA DEGRADATION Transport Translation PROTEIN PROCESSING DEGRADATION DNA RNA mRNA Protein Consequence of MIS-regulation: CANCER (Compare to bacterial Operon) How would you organize your chromosomes in your nuclei? Eukaryotic Nucleus and Cell Animal Cell Nucleus 10 m Size of Eukaryotic (Human) Chromosomes One average human chromosome= 1.5 X 10 8 nucleotide base pairs, which is approximately 4 cm long, which is 40,000 m 10 m nucleus Try this with 46 chromosomes in one nucleus!! Genome Packaging Histone proteins positively charged DNA genome negatively charged H2A X 2 H2B X 2 H3 X 2 H4 X 2 Histone Octamer + Basic unit of packaging= Nucleosome One nucleosome= ~146 nucleotides of DNA + histone octamer Chromatin= a nucleo-protein complex containing the genetic material Further packaging of chromatin Naked DNA 10-nm fiber...
View Full Document

This note was uploaded on 09/05/2009 for the course BILD BILD1 taught by Professor Bever during the Spring '08 term at UCSD.

Page1 / 25

Lecture%2020%20080605%20regulation - BILD 1 Lecture 20...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online