BIOS 255 week 7 Hemoglobin and Blood Oxygen Transport Worksheet.docx

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Model 1: Oxygen Binding to a Single Hemoglobin MoleculeHemoglobin (Hb) is a large molecule consisting of four peptide chain subunits. Each peptide contains a heme group with an iron molecule at the core. Each heme subunit can reversibly bind oneoxygen molecule and, interestingly, the bound/unbound state of each of the four hemes affect how easy it is for new oxygen to be bound and bound oxygen to be released. The number of oxygen molecules bound determine hemoglobin saturation, often expressed as 0 to 100%.Saturated Hemoglobin MoleculeQUESTIONS:1.How many oxygen molecules are bound when a hemoglobin molecule is completely saturated?2.How many oxygen molecules are bound when a hemoglobin molecule is 75% saturated?3.Assuming you started with the molecule in Model 1, how many molecules of oxygen would needto be released in order for the hemoglobin to be 75% saturated?
4.The number of oxygen molecules bound to hemoglobin tends to fluctuate up and down. (Discuss the following questions with your group, and then write your answer)a) Where in the body does oxygen bind to hemoglobin?
b) Where in the body are oxygen molecules released from hemoglobin?
5.Is it possible for one hemoglobin molecule to be 82% saturated? Why or why not?

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