Discussion 8 Fall 2008 - GENETICS (BIO 325) Discussion...

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GENETICS (BIO 325) FALL 2008 Discussion sheet 8 _____________________________________________________________________________ _ 1. A strain of yeast translates mRNA into protein with a high level of inaccuracy . Individual molecules of a particular protein isolated from this yeast have the following variations in the first 11 amino acids compared with the sequence of the same protein isolated from normal yeast cells. What is the most likely cause of this variation in protein sequence? Explain your answer. (Refer to the Codon table) (a) A mutation in the DNA coding for the protein (b) A mutation in the anticodon of the isoleucine tRNA (tRNA Ile ) (c) A mutation in the isoleucyl-tRNA synthetase that decreases its ability to distinguish between different amino acids (d) A mutation in the isoleucyl-tRNA synthetase that decreases its ability to distinguish between different tRNA molecules (e) A mutation in a component of the ribosome that allows binding of incorrect tRNA molecules to the A-site 2. A poison added to an in vitro translation mixture containing mRNA molecules with the sequence 5 -AUGAAAAAAAAAAAAUAA-3 has the following effect: the only product made is a Met-Lys dipeptide that remains attached to the ribosome. What is the most likely way in which the poison acts to
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This note was uploaded on 09/05/2009 for the course BIO Genetics taught by Professor Saxena during the Fall '08 term at University of Texas at Austin.

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Discussion 8 Fall 2008 - GENETICS (BIO 325) Discussion...

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