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10 - Paull BIO 212 Problem Set#10(12 pts Due on April 21/22...

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Paull BIO 212 Problem Set #10 (12 pts) Due on April 21/22 RFLP/sequencing/population genetics 1. (2 pts) Claude is doing a standard DNA sequencing reaction but makes a mistake and uses regular deoxynucleotides instead of dideoxy nucleotides. What does Claude’s sequencing gel look like when he develops it? 2. RFLP analysis can be used to correlate genotypes with phenotypes in humans. Shown below is a pedigree with corresponding RFLP data directly below. Part a (1 pt): which of the bands in the RFLP analysis are correlated with the disease phenotype? Part b (2 pts): which of the individuals in the pedigree are carriers of the disease allele but are not showing the disease phenotype? Part c (1 pt): what is the likely basis of inheritance for this disorder? a Æ b Æ c Æ d Æ e Æ f Æ g Æ 1.1 1.2 2.1 2.2 2.3 2.4 2.5 top bottom
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3. (3 pts) Albinism is a rare genetically inherited trait that is only expressed in the phenotype of homozygous individuals (aa). The most characteristic symptom is a marked deficiency in the skin and hair pigment melanin.
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