Lecture 3 (RS) (2009)

Lecture 3 (RS) (2009) - Review of ATP, enzymes and...

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Unformatted text preview: Review of ATP, enzymes and co-factors Lecture 3 Topics Lecture 3 Topics Esssentials of enzyme regulation Carbohydrate Catabolism Carbohydrate Catabolism Brief carbohydrate review First pathway ATP Electrostatic bond strain Ionization of ADP product Resonance stabilization of Pi (see Table 4) p. 4 Compound (hydrolyzed to) G o (kJ/mol) Transfer Potential Type of Compound Cause for G o of Hydrolysis Phosphoenolpyruvate (Pyruvate + Pi) - 62.2 62.2 Enolic phosphate Tautomerization of product (Pyr); Resonance stability of Pi 1,3-Bisphosphoglycerate (3-PGA + Pi) - 49.6 49.6 Acyl phosphate Ionization of product (3-PGA); Resonance stability (Pi, 3-PGA) Phosphocreatine (Creatine + Pi) - 43.3 43.3 Guanidine phosphate Resonance stability of product (creatine) Pyrophosphate (PPi) (Pi + Pi) - 33.6 33.6 Phosphoric acid anhydride Electrostatic bond strain in PPi substrate; Ionization and resonance stability of Pi group ATP (ADP + Pi) - 30.5 30.5 Same as PPi Same as PPi ADP (AMP + Pi) - 30.5 30.5 Same as PPi Same as PPi Acetyl-CoA (and other thioesters ) (Acetate + CoA-SH) - 31.5 31.5 Thioester No resonance stabilization of Acetyl-CoA; Ionization and resonance stabilization of acetate Glucose-1-P (Glucose + Pi) - 20.7 20.7 Phosphate semiacetal Bonds in glucose-1-P not that strained Glucose-6-P (Glucose + Pi) - 13.9 13.9 Phosphate ester Bonds in glucose-6-P not strained AMP (Adenosine + Pi) - 9.2 9.2 Phosphate ester Bonds in AMP not strained; Adenosine does not ionize Phosphate (Pi) 0.0 0.0 Phosphate Phosphoryl Phosphoryl -group group transfer potentials transfer potentials Receive Receive P~group P~group Donate Donate P~group P~group Review Review Enzymes (biological catalysts) Enzymes (biological catalysts) reaction rates (flux) can be regulated regulated coordinate coordinate many reactions into metabolic networks ( pathways ) via shared intermediates provide specificity and couple reactions Enzyme catalyzed reaction E E a R P Enzyme Classification Enzyme Classification 1....
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Lecture 3 (RS) (2009) - Review of ATP, enzymes and...

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