Lecture 9 (2009)

Lecture 9 (2009) - 15.6 Standard Deviation 71.3 Mean 24 Low...

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Unformatted text preview: 15.6 Standard Deviation: 71.3 Mean: 24 Low: 100 High: Lecture 9 Lecture 9 • Electron Transport Chain ( ETC ETC ) • “ Oxidative Oxidative ” Phosphorylation ( ATP Synthesis ATP Synthesis ) p. 21 Glucose Lactate Ribose-5-P Oxaloacetate Amino acids Ketone bodies Cholesterol Fatty acids ATP NADH Pyruvate Glucose-6-P Glycogen Acetyl-CoA NADPH NADH LIPIDS PROTEINS CARBOHYDRATES Glycolysis Glycolysis The The “Powertrain Powertrain ” of Human Metabolism (Overview) of Human Metabolism (Overview) O 2 CO CO 2 H 2 O PDH PDH Other Carbohydrates TCA Cycle TCA Cycle C O H 3 C ScoA C H 2 C O O- CH 2 COO- HO COO- C H 2 C O O- C CHCOO- COO- C H 2 C O O- HC H COO- COO- OH C H 2 C O O- C H H COO- O NAD NADH + H C H 2 C O O- C H H ScoA O NAD NADH + H + CO 2 COO- CH 2 CH 2 COO- GDP + Pi GTP + CoA-SH FADH 2 COO- C C-OOC H H C COO- C H HO H H COO- NAD NADH + H + ISOCITRATE α-KETO- GLUTARATE SUCCINYL-CoA C COO- H 2 C COO- O ACETYL-CoA CITRATE cis-aconitate enzyme-bound OXALOACETATE FUMARATE SUCCINATE MALATE 1 2 3 4 5 6 7 8 CoA-SH + H + 2 CO 2 CoASH FAD H 2 O H 2 O H 2 O H 2 O p. 45 The The Tricarboxylic Tricarboxylic Acid (TCA) Cycle Acid (TCA) Cycle Pyruvate Acetyl-CoA Succinyl-CoA α-Ketoglutarate Fumarate Isocitrate Malate Citrate Oxalaoacetate PEP Pyruvate Acetyl-CoA Succinyl-CoA α-Ketoglutarate Fumarate Isocitrate Malate Citrate Oxalaoacetate PEP Glu Glutathione Pro Ornithine Arg Purine Bases Gln Porphyrines Heme Chlorophyll Vitamin B 12 Asp Pyrimidine Bases Thr Met Asn Ile Lys Acetyl-CoA (cytosol) Fatty Acids Steroids TCA Cycle Biosynthetic Biosynthetic Functions of the TCA Cycle p. 46 p. 21 Glucose Lactate Ribose-5-P Oxaloacetate Amino acids Ketone bodies Cholesterol Fatty acids ATP NADH Pyruvate Glucose-6-P Glycogen Acetyl-CoA NADPH NADH LIPIDS PROTEINS CARBOHYDRATES Glycolysis Glycolysis The The “Powertrain Powertrain ” of Human Metabolism (Overview) of Human Metabolism (Overview) O 2 H 2 O Other Carbohydrates PDH PDH TCA Cycle TCA Cycle ETC ETC C 6 H 12 12 O 6 + 6H + 6H 2 O 6CO 6CO 2 2 + + 24e 24e- + 24H + 24H + Glycolysis Glycolysis – PDH PDH – TCA Cycle TCA Cycle 24e 24e- + 24H + 24H + + 6O + 6O 2 12H 12H 2 O ETC ETC 10 NADH/H 10 NADH/H + 2 FADH 2 FADH 2 C 6 H 12 12 O 6 + 6O + 6O 2 6CO 6CO 2 2 + 6H + 6H 2 O Overall H 2 O 2 H H 2 2 O O Explosion of the airship “Hindenburg” on May 6, 1937 H + + (in) (in) H + + (out) (out) Proton Motive Force Proton Motive Force (PMF) (PMF) NADH or FADH 2 O 2 Î H 2 O Electron Motive Force (EMF) H + + (in) (in) ADP ADP Î ATP ATP ATP Synthesis ATP Synthesis Proton Gradient Proton Gradient-- dependent ATP Synthesis dependent ATP Synthesis (1....
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Lecture 9 (2009) - 15.6 Standard Deviation 71.3 Mean 24 Low...

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