PE Thrombolytics

PE Thrombolytics - apy after heparin therapy has been...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Subsequent Management-Anticoagulation and Thrombolysis -I.V. heparin-stops further thrombus formation and extends the clotting time of the blood; it is an anticoagulant and antithrombotic. I.V. loading dose usually followed by continuous pump or drip infusion or given intermittently every 4 to 6 hours. Dosage adjusted to maintain the partial thromboplastin time (PTT) at 1 1/2 to 2 times the pretreatment value (if the value was normal). Protamine sulfate may be given to neutralize heparin in event of severe bleeding. -Oral anticoagulation with warfarin (Coumadin) is usually used for follow-up anticoagulant ther-
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: apy after heparin therapy has been established; interrupts the coagulation mechanism by interfer-ing with the vitamin K-dependent synthesis of prothrombin and factors VII, IX, and X. Dosage is controlled by monitoring serial tests of prothrombin time (PT); desired PT is 2 to 3 times control value. Reported as international normalized ratio (INR) of 2 1/2 by most laboratories. Anticoagulation is used to prevent new clot formation but does not dissolve previ-ously formed clots. Thrombolytics are used to dissolve clo...
View Full Document

Ask a homework question - tutors are online