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Unformatted text preview: apy after heparin therapy has been established; interrupts the coagulation mechanism by interfer-ing with the vitamin K-dependent synthesis of prothrombin and factors VII, IX, and X. Dosage is controlled by monitoring serial tests of prothrombin time (PT); desired PT is 2 to 3 times control value. Reported as international normalized ratio (INR) of 2 1/2 by most laboratories. Anticoagulation is used to prevent new clot formation but does not dissolve previ-ously formed clots. Thrombolytics are used to dissolve clo...
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- Spring '09