Lecture 1 - BIS101-001/Chan Lecture 1 Todays Lecture Course...

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BIS101-001/Chan 1/5/09 Lecture 1 Todays Lecture: - Course organization - Overview of topics in BIS101 - Mendelian Genetics quick overview - Review of Human Pedigrees Course Organization - See Course Information and Syllabus from the Smartsite course website for details. - BIS101D problems announced for week 1. Consult course website. - Review Quiz (take home) announced. Collect from Simon at office hours or lecture, or print out from course website. It’s due in class 1/23/08 Why study genetics and molecular biology? 1) The foundation of basic biology - study basic mechanisms of inheritance and biological information transfer - identify genes that control any biological process - ultimately understand disease mechanisms 2) Applications of molecular biology in research and engineering 3) Societal relevance - medical decisions and genetic information the influence of genomics - global warming and agriculture biofuels, and plant genetics - genetically modified organisms cloning genetically modified organisms and the environment Lectures 1-2 inheritance of genes, application to human pedigrees and sex determination Lecture 2 cellular mechanism of inheritance, mitosis and meiosis Phenotype vs. genotype How does a gene influence phenotype? Wild type = the most common form of a gene Allele = variant of a single gene. Genetic studies rely on differences between alleles that cause visible difference in the organism. We study their inheritance.
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Mutant = abnormal version of gene (vs. wt) Genetics uses mutations to study biological processes. Mutations allow us to identify genes involved in a particular process, and help us to study the process further. - Forward genetics: induce random mutations, screen for those defective in process of interest - Reverse genetics: start with a candidate gene we suspect is involved in a process of interest. Mutate that gene and see what happens. Lectures 3-4 relationship between phenotype and genotype interactions between different alleles of the same gene traits controlled by more than one gene Lectures 4-6 genetic mapping suppose we have an interesting mutation. How do we find the gene? localize it relative to genes whose position we know linkage = genes close together on a chromosome are less likely to be separated by recombination. Lecture 6-7 bacterial genetics for basic biology and human disease relevance bacterial gene mapping bacteria as a tool in molecular biology research The Central Dogma of Biology posits that: DNA-> mRNA-> protein RNA molecules have been found to play important roles in the cells, so not all genes encode proteins. This central dogma cartoon reminds us of the properties required of the genetic material: 1. It must be able to replicate itself and then be distributed to new cells. This occurs every time a cell divides as an organism grows, and during the production of sex cells – the gametes – which will pass the genetic material to the next generation. 2.
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This note was uploaded on 09/07/2009 for the course BIS BIS 101 taught by Professor Sanders during the Spring '09 term at UC Davis.

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Lecture 1 - BIS101-001/Chan Lecture 1 Todays Lecture Course...

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