Lecture 2 - BIS101-001 Lecture 2. 1/7/09 Mitosis and...

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BIS101-001 Lecture 2. 1/7/09 Mitosis and Meiosis Sex-Linked Genes
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LECTURE 2: OUTLINE Mitosis and Meiosis Formation of haploid gametes Mechanism of meiosis {Mitosis and meiosis with pool noodles} Sex determination Sex-linked inheritance Dosage compensation Human genetics Pedigree analysis Modes of inheritance
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What is the purpose of mitosis? - ensure that when a cell divides, both daughter cells receive one copy of every chromosome
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The cell cycle: DNA replication must be completed before mitosis
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2N, 2C 2N, 4C
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2N, 2C 2N, 4C
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What is the purpose of meiosis? -starting with two copies of each chromosome (diploid organism = 2n), create gametes that have only one copy of each chromosome (haploid gamete = 1n) -Reduction in ploidy is required for sexual reproduction
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2N, 4C 2N, 2C a A a A A a a a A A
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2N, 4C A A a a A A a a A A a a
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2N, 4C 1N, 2C 1N, 1C a a A A a a A A Reductional (ploidy 2N -> 1N) Equational (ploidy 1N -> 1N) a a A A a a A A a a A A a a A A
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Chiasmata (BERNELOT-MOENS, P.B. MOENS, 1986)
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Down’s Syndrome U.S. Department of Energy Human Genome Program; http://www.ornl.gov/hgmis.
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A diploid cell contains two pairs of homologous chromosomes. Each pair is heterozygous for a pair of alleles, Aa and Bb respectively.
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This note was uploaded on 09/07/2009 for the course BIS BIS 101 taught by Professor Sanders during the Spring '09 term at UC Davis.

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Lecture 2 - BIS101-001 Lecture 2. 1/7/09 Mitosis and...

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