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Lecture 5 - BIS101-001 Lecture 5 Genetic mapping Three...

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BIS101-001 Lecture 5. 1/21/09 Genetic mapping: Three point crosses
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Announcements - Please hand in your review quiz today! - Midterm 1 is next Wednesday 1/28 in class. Covers material from lectures 1-5 - Extra midterm review session Giedt 1002 Friday 1/23 3:40pm-5pm Bring questions! - Practice midterm on course website (“Resources” section)
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DNA can reveal ancestors' lies and secrets http://www.latimes.com/news/local/la-me-dnasurprise18-2009jan18,0,5045230.story As genetic testing becomes more widespread for medical information, forensics and ancestral research, more people are accidentally uncovering family secrets. Among the most painful are so-called "non-paternity events," cases in which Dad turns out to be someone else. "It's going to be more and more of a problem," said Dr. Eric Topol, chief of genomic medicine at Scripps Research Institute in La Jolla. Increasing numbers of people will be asking their spouses and parents: "What happened 25 years ago?"
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What is the average frequency of non-paternity? A) 0.4% B) 1.2% C) 4% D) 16%
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- The most common scenario … an affected child with an autosomal recessive disorder e.g. cystic fibrosis. - If the mother is heterozygous for the causative mutation, can a homozygous WT man be the biological father? A) Yes B) No C) Maybe, but it s very unlikely
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“Breaking the news falls to genetic counselors, who often must balance competing ethical imperatives… Standard practice is to tell only the mother, who usually already suspects it” Would you tell the father? A) Yes B) No C) prefer not to answer
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“Breaking the news falls to genetic counselors, who often must balance competing ethical imperatives… Standard practice is to tell only the mother, who usually already suspects it” don t tell: possibility of violent relationship tell: what if father wants more kids? Unnecessary testing of future unborn children could be dangerous Would you tell the father? A) Yes B) No C) prefer not to answer
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LECTURE 5: OUTLINE Why build genetic maps?
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