LC 3 BIS 103

LC 3 BIS 103 - Overview of metabolic pathways Sterols PPP...

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Unformatted text preview: Overview of metabolic pathways Sterols PPP Glycolysis three stages: investment, C-C cleavage, harvest Activation energy investment cleavage Oxidation energy gain Glucose C6 2x C3 2x Pyruvate C3 ! G Glycolysis three stages: investment, C-C cleavage, harvest phosphorylation cleavage oxidation 1 2 3 5 4 6 7 8 9 10 Glycolysis stage 1: substrate activation, isomerization 1 2 3 Glycolysis three stages: investment, C-C cleavage, harvest phosphorylation cleavage oxidation 1 2 3 5 4 6 7 8 9 10 Glycolysis stage 1: substrate activation, isomerization 1 2 3 Mg 2+ Glycolysis stage 1 : activation by phosphorylation (Kinase) 1 Glycolysis stage 1 : mechanism. Hexokinase induced fit binding site glucose causes conformational change hexokinase:- high affinity- inhibited by Glc-6-P- low substrate specificity (e.g. fructose, mannos) glucokinase (hexokinase D):- in liver and "-cells- lower affinity- not inhibited by Glc-6P- high substrate specificity Glycolysis stage 1: kinase substrate specificity glucose enzyme activity Glycolysis stage 1: phosphoglucoisomerase works near equilibrium 2 Mg...
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LC 3 BIS 103 - Overview of metabolic pathways Sterols PPP...

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