BearCh06-ACRQedt - Chapter 06 Neurotransmitter Systems...

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Chapter 06 – Neurotransmitter Systems Answers to Chapter Review Questions Page 1 of 5 Copyright © 2007. Lippincott Williams & Wilkins. Ancillary material to accompany Bear et al.: Neuroscience: Exploring the Brain, 3e Question 1: If you could place microelectrodes into both a presynaptic and a postsynaptic neuron, how would you determine whether the synapse between them was chemically or electrically mediated? Answer: A microelectrode placed in the presynaptic and postsynaptic neuron would show different results for electrical and chemical transmission. For electrical transmission, the two electrodes would show identical or similar changes in electrical activity, i.e. , the action potential in the presynaptic membrane would produce an action potential in the postsynaptic membrane. Chemically mediated synapses operate differently. An action potential in the presynaptic membrane causes neurotransmitter release in the synaptic cleft, and the postsynaptic membrane might respond to the neurotransmitter with changes in conduction, but not an action potential. An action potential is generated in the postsynaptic neuron of a chemically mediated synapse only if the whole neuron is sufficiently depolarized. This action potential would not be evident in a postsynaptic dendrite or cell body (typical synaptic sites); you would have to record for the axon of the postsynaptic neuron. Question 2: List the criteria that are used to determine whether a chemical serves as a neurotransmitter. What are the various experimental strategies you could use to show that ACh fulfills the criteria of a neurotransmitter at the neuromuscular junction? Answer: Three certain criteria must be met for a molecule to be considered a neurotransmitter. 1) The molecule must be synthesized and stored in the presynaptic neuron. 2) The molecule must be released by the presynaptic axon terminal upon stimulation. 3) The molecule, when experimentally applied, must produce a response in the postsynaptic cell
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This note was uploaded on 09/09/2009 for the course SPHSC 449 taught by Professor Peter during the Summer '09 term at University of Washington.

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BearCh06-ACRQedt - Chapter 06 Neurotransmitter Systems...

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