22_Plasticity - Neural Plasticity Susan McLaughlin 8/09...

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Neural Plasticity Susan McLaughlin 8/09
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Neural Plasticity Rough definition Changes in how the brain functions involving modification of neural structures/circuits in response to changes in input New input coming in, changes in salience of input: development, learning Increased input: training, enriched environment Decreased input: deprivation, peripheral damage
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Some manifestations of neural plasticity Plasticity that accompanies development Critical periods But even after development/critical periods over, some level of neural plasticity remains Learning and memory throughout life Cortical reorganization in response to changed environment, neural injury
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Some possible mechanisms of neural plasticity Growth of new neurons: “neurogenesis” Growth of new dendrites, axons: synapses Pruning of synapses (axons, dendrites) Rerouting, “rewiring” of axons, dendrites Regeneration of damaged neurons, axons, and/or dendrites Altering the strength of a given synaptic input Unmasking, disinhibition of previously silent circuits Other?
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Overview of lecture Learning-related plasticity, possibly associated with changes in synaptic strength? Evidence Primary hypothesis regarding cellar basis: Hebbian learning Plasticity-related to increases/decreases in input, possibly associated with synaptogenesis, dendritic branching, rerouting of connections? Evidence Neurogenesis in adults Evidence
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Learning-related plasticity: some evidence Kilgard & Merzenich, 1998
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Hypothesized cellular bases of Donald Hebb (1904-1985) Interested in connecting brain and behavior Hebb s Law/Hebbian Learning Hebb wrote, When the axon of cell A excites cell B and repeatedly or persistently takes part in firing it, some growth
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This note was uploaded on 09/09/2009 for the course SPHSC 444 taught by Professor Peter during the Summer '09 term at University of Washington.

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22_Plasticity - Neural Plasticity Susan McLaughlin 8/09...

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