04102009f (3) - Functional group transformations Most of...

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CH 310M/318M – MWF 9:00 – Lecture 35 – F 4/17/2009 Last Time : Mechanism of alkyne oxymercuration (continued…) Reduction reactions of alkynes Synthesis problems in organic chemistry Reading Assignment : No new reading… Textbook Problems : 8.4, 8.14-8.18, 8.20, 8.21 (last Midterm #3 problems) Graded Homework : HW#17 deadline = 3:00 p.m. on Mon 4/20 (last HW due before Midterm Exam #3) Today : Synthesis problems in organic chemistry (SEE THE ONLINE HANDOUT THAT HAS BEEN POSTED IN BLACKBOARD…end Chapter 7) Structure, nomenclature, and physical properties of alkyl halides – PLEASE READ AND UNDERSTAND SECTIONS 8.1 THROUGH 8.3!!! YOU WILL BE RESPONSIBLE FOR THIS MATERIAL!!! Preparation of alkyl halides via radical halogenation of alkanes Midterm Exam #3 is scheduled for Thursday, 4/23, from 7:00-9:00 p.m. Exam coverage will include all material discussed through the end of today’s lecture. The detailed “Exam Information” sheet will be posted this weekend…
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There are 3 types of operations involved in organic synthesis:
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Unformatted text preview: Functional group transformations Most of the reactions you have learned at this stage are examples of a functional group transformation one functional group is converted into another functional group during the course of the reaction Control of stereochemistry If a particular stereoisomer of the target is desired, use of stereoselective reactions will be necessary during the course of the synthesis. Several of the reactions you have learned thus far allow for stereochemical control (syn addition vs. anti addition) Formation of CC bonds Since the goal of organic synthesis (in the real world, at least) , is to build up complex target compounds from simple (and inexpensive) starting materials, reactions that form carboncarbon bonds are typically of tremendous importance in synthesis. At this stage you only know one reaction that leads to formation of a new CC bond alkylation of an acetylide ion by treatment with a methyl or 1 alkyl halide....
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04102009f (3) - Functional group transformations Most of...

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