Quiz 2 key

Quiz 2 key - – RT makes a dsDNA copy of the viral RNA...

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Total score ___________ (50) Name ___________________________________________ BICD 136 Quiz 2 Winter 2009 By signing below, I give permission for my quiz to be available for pick-up in the third-floor hallway of Pacific Hall. I understand that this means my exam might be viewed by persons without my permission and that it might be stolen. _______________________________________________________________ signature (50) 1. Clearly describe the complete life cycle of HIV. Include all of the pertinent viral components described in lecture and explain their roles. You may continue on the back if necessary. a) adsorption – gp 120 binds to CD4 and the coreceptor (CCR5 or CXCR4) on the cell membrane. (6) b) penetration — gp41 harpoons the cell membrane and pulls the two membranes together. (4) The viral envelope fuses with the cell membrane, releasing the core into the cell. (2) The capsid is shed, releasing the viral RNA and enzymes into the cytoplasm. (2) c) production of viral components
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Unformatted text preview: – RT makes a dsDNA copy of the viral RNA genome. (4) The DNA copy and integrase migrate into the nucleus. (3) Integrase mediates the random insertion of the viral DNA into a chromosome, forming the provirus . (4) The cellular machinery expresses the viral genes. viral DNA (1) transcription (2) viral RNA (1) exported from nucleus (2) viral messenger RNA viral genomic RNA translation packaging viral proteins nucleic acid of new viruses used in different ways (2) (2) d) assembly and release of new viruses – Env proteins insert into plasma membrane as they are synthesized. (2) Other structural proteins, enzymes, and RNA are assembled into icosahedral cores. (4) The progeny virions wrap themselves in matrix protein and a swath of cell membrane, as they bud off from the cell. (5) e) maturation – After the virus has budded from the cell, the protease will further cut the capsid proteins and remodel the capsid into a bullet shape. (4)...
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Quiz 2 key - – RT makes a dsDNA copy of the viral RNA...

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