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bibc 100 final differ

bibc 100 final differ - Name Student ID Qm-Pm BIBC1OO g...

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Unformatted text preview: Name:_ Student ID #. Qm-Pm BIBC1OO g ”0 FINAL EXAM WINTER 2008 Student ID #:_ 8180 100 FINAL EXAM SECTION I WINTER 2008 CHOOSE ANY 4 OUT OF THE NEXT 5 QUESTIONS TO ANSWER. 5 points each. WRITE "OMIT" in LARGE LETTERS ON THE PAGE YOU DON’T WISH TO ANSWER. 41) Draw a diagram of a three-stranded, antiparallel B sheet. Show the exact placement of main chain atoms. Be sure to indicate the pattern of hydrogen-bonding, and indicate where the R groups are situated relative to the main chain. g I‘\ Q\ \ \\ 2—- d '—~§- 91—— 01. U 3: O I/ / / ‘- . .31: :1- 7. '5. :21 \ \ ,r \ x \ , -' —- rd. ”‘0 40 I"; _. / / are” "L d'fi-U :U x \ \ J. \ 3V T. Zi 123' k d — / / ‘\ / 9:1.) :10 ‘3- Ohw'\ H1 cue «Awe—15 SLt-ucded w“ W m ream fiwuohdt We. a basic \a’w Ci? cw} MW. Name:_ Student ID #:_ 42) What are three similarities between the cataMic activity of chymotrypsin and protein kinases? What are two differences? (It is me to list "Similarities: 1 ...... 2 ..... 3 ...... Differences: 1 ........ 2 ...... ") who. (sedans of M6 (Jasmin. $1M “gnaw Maw W flu," . '. ' 2" mmtpfi‘i‘xxt ‘v‘fifibak, “5*" mt'hvcg dfi‘r‘mn‘E/ @ gum WW USE ‘( M, 0” W5 in Mmtruififfiw (15¢er chad?“ oh! Ma 1-» \ Digflewofis n I: cad-S to A.\/ —.____ Naml Student ID # 43) The review article (Huse and Kuriyan, 2002) states "ATP is bound in a deep cleft between the two lobes and sits beneath a highly conserved loop connecting strands [31 and [32. This phosphate binding loop, or P loop, contains a conserved glycine-rich sequence motif (GXGerG) where (p is usually tyrosine orhphenylalanine. The glycine residues allow the loop to approach the phosphates of ATP very closely and to coordinate them via backbone interactions." Which atoms in the loop coordinate the phosphates? Illustrate this through a diagram. Name; ' Student IE 44) Explain through text and diagrams, or any other method, how the MHC Class I + peptide and T—cell receptor interface is formed (Explain how the protein structure allows a given T-cell receptor to recognize an MHC Class I receptor and bound peptide). Nam Student ID 45) Why is it energetically unfavorable for a K+ ion to pass through a membrane? How does the K” channel from Streptomyces iividans (the channel discussed in lecture and in the book) overcome this problem and allow K" ions. but not the smaller Na” ions, to pass through the bacterial membrane? (a diagram would be a useful part of this answer) ‘1' '6 Wfiefic‘mkj Mam gear 0 ‘F‘ Inn 4‘0 QoSQ M‘s-sin aW‘ach / because m was dim-<32 LAN ms ohm: 6r *0 goss- «wmgn ion «sword. mmw ELF as, m M wswnqs \oijar la (:sz WW- W 1M HWY?“ ls wag “‘3 0C 8 ”Cum On. Nlus, 2 Puma. God-03 (ks Mom subunits. 'llre. CW\ %-\g {5 MM yea magi 4M. WW W69 d? M Wm M wad M 4m; {an 4.3 mtw‘m 3%».th lfi" IS Eta-Aw QR. NJ" ,ch W“ M N W\ even Mk 6 \"5 like a Viva We. 1“; and. \ audit“ M Q” \on W 0&3 “3% fl thug- Ghana-vi (ye M Var (“9‘5“ 1p “AI-3 g‘k \Ll-‘JM; Mafia WV co. N413" . 1h. wage»; mm lul— l'n 05V. +9 qeadn 4". as; 5&4th \g 1 " we. ‘qlbwth lass in Ms Case. Became: K ‘5 m ”W W- l“ ‘ “M5“ l” ”NWT? ll 9 o =C>® C3" :0 @Q; / é: m. E E “N“; Nam Student ID SECTION II ANSWER ALL OF THE QUESTIONS IN THIS SECTION. Two points each. NO PARTIAL CREDIT! 46) Which amino acids have branched hydrophobic side chains (non-aromatic)? (can use the full name, one letter or three letter codes) 26%??? as“ TEL/47) Which amino acids have charged side chains? Indicate the charge for each amino acid in your answer. “3%“th f. D; E Qas'rrhufi". flirt-7 R ..._ 48) Which amino acids have aromatic side chains? Draw the side chain for one of r' 9'" these amino acids (indicate which a.a. side chain you are drawing). \ W :5 I g: 9km ~3\Q\Qnim"— $2 - (9 49) Which amino acids have ail-ridegroups in their side chains? Draw the amide group , contained in these amino acids." ' —~ u raw the structure of this side @ 50) Which amino acids' side chain is only weakiy acidic? chain. \ E E E E His i ~ C. ' Q. C “)0“. CH2 0‘)!” H Ci“: 3 (5:31); 3‘ ("*3 Pb c. =‘=' H NH}. m; ’i '_/ 51) What is the name of the prosthetic group contained in myoglobin? What unusual atom (for organic molecules) does this prosthetic group contain? HERE. W. ?€z*‘ .3 52) Give one example of an unusual (not one of the standard 20) amino acid contained X "l in some proteins? (hint: collagen) hfiwxr .. 9mm, ii 53) If you were to replace Ser195 in chymotrypsin with some other amino acid, which ‘Vsubstitution might you predict would have little to no effect on chymotrypsin catalytic activity? "Manama N Student ID 3' 54) What molecule acts as a fluidity buffer in eukaryotic cell membranes, preventing them from altering their state dramatically ift perature increases or decreases? " .‘.\ 1' / My: 14’ 55) Draw the general structure of a glyggrgghosgholipid. Label the major component parts of this type of molecule. 56) Draw the head-group structure of one of the commo% uncharged glycerophospholipids. I‘M; A «g: mac? We can? s? CH2 Wfi Ems-Q, t Q Ma\ *CR peskm («Mafia and tie-g3 57) An gfifiayg, modulator, generally a small metabolite. regulates certain enzymes through reversible, noncovalent binding. 58) The technique used to change one amino acid in a protein, or swap a stretch of amino acids from one protein to another in order to dissect protein function, is known 35: gm mfihhch / 366.0 cum 1, (. 59) What is one name for the type of receptor that responds to odorant molecules (binds to them)? 3W“? W“‘-"/ twat“ {WM-5- ,L 60) What is the name of the small signaling molecule that binds to the regulatory subunits of PKA? What is the name of the compound (not the enzyme) that is used to generate this signaling molecule? /! / ...
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