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BIPN100midterm2 fortes

BIPN100midterm2 fortes - BIPN 100 Mammalian Physiology I...

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Unformatted text preview: BIPN 100, Mammalian Physiology I Name: “[3 Winter, 2008 2nd. Midterm Exam ID. #2 February 29, 2008 Page 1 1. (12 points) List the following parameters for the branches of the autonomic nervous system: Sympathetic: Parasympathetic: Preganglionic axon length: $7/w1"+ 3 Postganglionic axon length: \31‘ Preganglionic neurotransmitter: Ace low ’48 CZW k1 Postganglionic neurotransmitter: NWWM/W Ace {6% N1 asthma ’4 all Cite/magic Muycar/Iilé Postganglionic cell neurotransmitter receptor: Nlcoi’wua :4th Target cell neurotransmitter receptor: 41 mot-j [ c, \>< orig, 2. (12 points). Ten years ago, a friend of Dr. Fortes, the Chairman of the Dept. of Physiology at the University of Copenhagen, was near death owing to a genetic disease that destroyed his lungs and ruined his heart. He received a double lung and heart transplant, and he is alive, well, and working. Despite not having any nervous input to his new heart and lungs, his resting heart rate is ~100/min and his heart rate increases and his bronchioles dilate when he exercises or gets startled (true story!). Explain why his resting heart rate is higher than normal and list the signal, its source, and the receptors that stimulate his heart during exercise. [luflwkuc nevi/:5 fax 045/ fims‘jmffifl'lfic. 2‘9" fiW #1 141le heft/e, 3. ( 12 points). Briefly describe the function of gamma motoneuron activation during muscle contraction. c {m CmfilraCkém #4 a?!“ M [£40 W376 1:24;: $44 (Miracfiim 57((87LCA25 mfimfi Mr): M .f’ M1; my 2; red “dimmer W l Lemmamwio’é. P BIPN 100, Mammalian Physiology I Name: fl’mfifl 1? FY Winter, 2008 2nd. Midterm Exam I.D. #: February 29, 2008 Page 2 4. (12 points). Phenylephrine is an al- adrenergic agonist used in nasal sprays to constrict arteriolar smooth muscle to treat runny noses. It causes an increase in intracellular Ca++ without changing the membrane potential. Diagram the signal transduction pathway that results in increased Ca++ after adding phenylephrine. cf vaieci “he éhvmtes 3 mi“ 78/645195 Ctbe binds E‘T/oi'ffie NV Myvfikf’fifiiimks ‘flozpkehfimse C whicir hfhflvljw PIPZ \N’ who bAér £0! 18,; I95 rffiaes~lom mtg ‘ C4 fiaSMtC M'hc‘u/aa,‘ 4M9 spews Qfichw. “Hie glam”. w releang TD 5. (20 points). A. List the sequence of steps that cause milk production in a lactating mother. Include the stimulus a‘n/d/he hormones their sources and their targets and actions. N Am; 4w“ m a mac; WA W 5‘ 2: “9‘31 ‘er o W wwkéznhlbflflpzéflzfimw <19 ‘met . Afmty/M w} Willi Pralacifn Senehw Hitteawlw'or“ Pnlw' . a Rahal/n sec-telly WWW ”Oi/Cd; 5 ind/ale; #2 hen; ”713'pr m4 B. Explain briefly why nursing mothers do not get pregnant. ? a 4‘,“ '114'6}; “Hm res *Hwaafmer rial» "[3 3.9/4. ‘mméimétofi; in; $544 Marmara no+ secretefwl db Mend/fl? 1% 49va DVUlculc, N0 ova/Men ~—> mfrejmna}. 6. (20 points). A. Draw a graph of an action potential in a ventricular myocardial cell, labeling the axes with the proper units. Indicate the ion channels and their state (open/closed) that are responsible for each of the phases of the action potential. {Channels Cl°$€ Z /{¢Ztfllzhkaurels c lose V“ +20 was «9 e41 , ~I K+ la is 0 314 3h (“\b O 4/ Zifpwje/s “(n/Eye “250% ”‘9 B. Why can’t the myocardial contractile cells be tetanized (have a sustained contraction)? BUM/1c “Hm musde, Yelaxes 51m ”Hm: ”lie mfmc‘ierj Panooi id W94; BIPN 100, Mammalian Physiology I Name: ”ANSWER KEY Winter, 2008 2nd. Midterm Exam I.D. #: February 29, 2008 Page 3 7. (27 points). Briefly describe the role of each of the following proteins in Excitation-Contraction coupling or muscle contraction for each type of muscle fiber. Write “No Function” if the orotein does not have a function in that muscle . . Muscle Voltage sensing receptors in T- Dihydropyridine tubule that sense . . Receptors (DHP) action potential and No Function N0 Function mechanically open R Rs Create action Action Potential down potential and allows T-Tubule cause these No Function Ca++ to enter the cell channels to open and to carry out allow CaH to enter the contraction cell Release CaH from Release CaH from Sarcoplasmic Reticulum upon No Function DHP mechanical activation Bound by Ca4+ to allow. actin-myosm No Function binding for contraction to occur No Funaion Voltage-gated Ca” channels Ryanodine Receptors Reti::lriiiii)1:133:11CCaH (RYR) influx from V-G CaH channels CaH ions bind troponin Troponln to initiate contraction 1 Ca ion is exchanged with 3 Na+ ions to decrease intracellular [CaH] and lead to relaxation of cardiac muscle cell NaVCaH-exchanger Binds CaH as the Calmodulin No Function first step‘in the No Function cascade to imtiate a contraction 8. (12 points) Draw the electrocardiogram you expect in a patient that suffered a lesion that blocks conduction between the atria and the A-V node. Indicate the correct letters corresponding to each wave and note any abnormal or missing waves, as well as whether the waves will be rhythmic or not. Will the ventricles and the atria contract at the same rate in this patient? P . ? l: g p \ \xx “RM a,“ ..... v P waves M QRS Twavfs are fit Mic Wk)“; 0;" JAFW fit?" “We W”W¢W* 4+ 5 luglur r4 4% +234 W ...
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