practice-exam2 - Name:_ MCB100A/CHEM130A Practice Exam- I I...

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Name:_____________________________________________ MCB100A/CHEM130A Practice Exam- I I 12-02-05 (Aathavan) 1. Choose your own levels of stringency – no cheat sheets/ cheat sheets/ open book 2. DON’T PANIC if it appears difficult. Nothing in here is beyond the domain of what you already know. Just clear your heads and think 3. Remember that this may not be representative of what’ll be on the exam. 4. The exam may have errors (considering the time constraints). 5. Have fun! I. Chemical Potential: (10) A. What is the chemical potential of the black dots in the following system. B. What is the chemical potential of a particle in a box, if there are M grid points and N particles?:
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II. Pressure Induced protein unfolding: (10) Consider the following equilibrium of a protein unfolding reaction. F <----> U ΔG = 20kJ/mol (300K, 1 atm) When you apply very high pressures on this protein, it unfolds. At 100atm you find equal proportions of folded and unfolded states. The volume of the folded state is 1 litre/mol. What is the molar volume of the unfolded state. III. Spontaneity (5) (from JKs PS from Chang) Under standard-state conditions, one of the steps in glycolysis is as follows: Glucose + HPO4 2- ---> Glucose-6-phosphate + H2O ΔGo = 13.4kJ mol
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A. Will it occur spontaneously? B. Can the reaction take place in the cytoplasm of a cell where the concentrations are [glucose] = 4.5x 10-2M [HPO4] = 2.7 x 10-3 M [glucose-6- phosphate]=1.6 x 10-4M and the temperature is 300K IV. Abzymes: Antibody-enzymes (based on Janda et al, Science, 1989) (25) A. Consider the following mechanism for an ester hydrolysis reaction.
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The rate constant of this un-catalyzed reaction is 9.3 x 10 -7 s -1 . Let us also say that the transmission factor will be given by υ=kBT/h where h is Planck’s constant (=6.6 x 10 -34 J.s). A. What is the height of the reaction barrier? What will be the concentration of the
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This note was uploaded on 09/14/2009 for the course MCB 100A taught by Professor Kuryian during the Fall '09 term at University of California, Berkeley.

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practice-exam2 - Name:_ MCB100A/CHEM130A Practice Exam- I I...

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