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Chemical Synaptic Transmission Review

Chemical Synaptic Transmission Review - Vert phys Chemical...

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Vert phys Chemical Synaptic Transmission 1. Iontophoresis 2. Excitation increase permeability of Na ions. Inhibition increases permeability of K and Cl ions 3. Reversal potential at the synapse is where equal amounts of K+ and Na+ are entering and exiting the cell when both are released at ACh receptors. 4. Positive current will enter the membrane during the action of the transmitter. The synapse is excitatory because the reversal potential is -50mV, while the threshold is -55mV, which will cause an AP to fire. The -30mV will produce the largest EPSP. 5. Quantal hypothesis is that there is a specific amount of ACh released from each vesicle during the action of the transmitter. Katt’s experiment where he stimulates the nerve in a solution of low Ca concentration. Cells fired in increments of 0.4mV. 6. The drug acts on the Ca++ receptors and decreases the conductance of Ca++ into the membrane as an action potential passes through. Some Ca++ will get through, but not enough to trigger an EPSP 7. The transmitter binds to two different receptors. One that opens Na channels and one that
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