Lecture 13 - Review Session Wednesday Night WRW 102 68 pm...

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Review Session  Wednesday Night WRW 102 6-8 pm
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Outline Lecture 13 Review Long-Term Depression G-protein coupled Receptors Amplification of signal Direct and indirect changes in membrane potential Down stream signaling to nucleus Location, Location, Location
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LTP promotes new spine growth
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Problem: If synapses continue to increase in strength as a result of LTP, eventually they would reach some level of a maximum efficiency, making it difficult to encode new information. There must be a process to weaken specific sets of synapses. Long-Term Depression
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Paradigm that induces  LTD Low frequency stimulation for a prolonged period of time. This patter n of activity depresses the EPSP for several hours LTD can erase the increase in EPSP amplitude due to LTP LTP can erase the decrease in EPSP amplitude due to LTD
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NMDAR dependent LTD Low frequency stimulation induces NMDA dependent long-term depression. Calcium enters the cell and activates PP1 which removes the phosphates from AMPARs AMPARs are removed from the synapse by endocytosis. Internalization of AMPARs may lead to spine loss
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How do NMDARs mediate both LTP and LTD The major determinant whether LTP or LTD arises appears to be the nature of the calcium signal in the postsynaptic cell. A small and slow rise in calcium lead to LTD A large and fast rise in calcium lead to LTP LTP activates kinases and LTD activate protein phosphatases.
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Summary of the Molecular Basis For Bidirectional Synaptic Plasticity It’s likely that PP1 – the phosphatase that is activated in LTD dephosphorylates the same substrates that are phosphorylated by kinases activated during LTP
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Signal Transduction at the Synapse Presynaptic Nerve terminal Neurotransmitter Postsynaptic cell Intracellular signal transduction
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Two Super Families of Neurotransmitter Receptors Iontropic receptors Metabotropic receptors
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Activation of a single metabotropic Receptor Can lead to the activation of many G-proteins in the cell
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Metabotropic Receptors 7 Transmembrane domains Function as dimers Coupled to trimeric G proteins α and βγ subunits have different target molecules or effectors
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Nature Reviews Cancer
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This note was uploaded on 09/14/2009 for the course BIO 365R taught by Professor Draper during the Spring '08 term at University of Texas.

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Lecture 13 - Review Session Wednesday Night WRW 102 68 pm...

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