x2-fall08 - Multiple-Choice, 3 points each, 60 points total...

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1 Multiple-Choice, 3 points each, 60 points total For each of the following questions, encircle the letter corresponding to the BEST response. 1. Which of the following is NOT an assumption made in the derivation of the Michaselis-Menten equation? A. The reaction proceeds with a large, negative change in free energy. B. The rate of formation of ES is balanced by the rate of its destruction, either to E + S or to P + E. C. The k -2 step can be ignored. D. Only one substrate is considered. E. (All of the above are assumptions usually made.). 2. Which of the following correctly defines K M ? A. It is equal to the quantity k 1 /(k -1 + k 2 ) B. It is the dissociation constant for the enzyme-substrate complex. C. It is equal to V max /2. D. It is the substrate concentration giving half-maximal velocity. E. It is equal to the quantity k -1 /(k 1 + k 2 ) 3. Iodoacetate inactivates glyceraldehydes 3-phosphate dehydriogenase. Which of the following best explains its mechanism of action? A. It combines with the –SH group of cysteine. B. It forms a covalent bond with the –OH group of Ser. C. It competes with glyceraldehyde 3-phosphate for the substrate binding site. D. It binds to the Asp residue in the catalytic triad. E. It interferes with proton exchange by the sidechain of Lys. 4. Which statement about a hemoglobin molecule is INCORRECT? A. There are four polypeptide chains non-covalently associated. B. Each polypeptide chain is associated with one porphyrin ring. C. There is a total of four Fe 2+ atoms in oxyhemoglobin. D. One BPG can bind to each αβ dimer. E. HbA 2 contains α and δ chains.
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2 5. Which of the following statements about the X-ray structure of myoglobin is INCORRECT? A. There are eight regions of α helix. B. The regions between the helices frequently contain Pro or β turns. C.
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This note was uploaded on 09/14/2009 for the course MCB 450 taught by Professor Mintel during the Summer '07 term at University of Illinois at Urbana–Champaign.

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x2-fall08 - Multiple-Choice, 3 points each, 60 points total...

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