Linda%20study%20guide%20week%2011 - the carbonyl oxygen...

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Chemistry 232 Study Guide Week 11 (Exam 3 Material) Linda Johnson: [email protected] AIM Screen Name: Chem232Linda Carbonyl Chemistry O CH 3 alpha hydrogens are slightly acidic oxygen has partial negative charge carbonyl carbon has partial positive charge Three main types of carbonyl reactions: 1. addition 2. substitution 3. reactions at the alpha carbon VERY IMPORTANT!!! In acidic solution , all intermediates that you draw should have a positive or neutral charge Start reaction by protonating
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Unformatted text preview: the carbonyl oxygen, then the nucleophile attacks carbonyl carbon to form an alcohol. In basic solution , all intermediates that you draw should have a negative or neutral charge Nucleophile adds directly to carbonyl carbon , creating a negatively charged oxygen (which can then be protonated to form an alcohol). Addition of Grignard Reagents to Carbonyls: Creating Alcohols O 1. CH 3 CH 2 MgBr 2. H 3 O O CH 3 Ph 3 P CHCH 3 CH 3 CH...
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