LungCancer - Lung Cancer Genes Identified - Printout - TIME...

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Back to Article Click to Print Page 1 of 3 Lung Cancer Genes Identified -- Printout -- TIME 2008-11-02,8816,1727161,00.html
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Wednesday, Apr. 02, 2008 Lung Cancer Genes Identified By Alice Park Smokers are much more likely to develop lung cancer than nonsmokers — that has been a scientific truism for decades. But what about the 80% of smokers who don't develop lung cancer? Are they just the lucky ones? A trio of new studies suggests that the explanation for why they escape the disease may lie partly in their genes. Three new reports by research teams in the U.S., Europe and Iceland have identified, for the first time, specific gene variants that appear to make some smokers and former smokers more susceptible than others to cancer. Th two variants — or differences in a single nucleotide — exist in about 34% of the population and occur in genes in the same region of the long arm of chromosome 15. Those genes code for nicotinic acetylcholine receptors, cell- surface proteins that selectively bind to nicotine molecules. Once nicotine attaches to these receptors, a series of changes in the cells is triggered: in the lungs, for example, cells are pushed into rapid, uncontrolled growth, which promotes the growth of new feeder blood vessels, creating, in turn, a particularly hospitable environment for
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This note was uploaded on 09/14/2009 for the course CH 310 N taught by Professor Blocknack during the Fall '08 term at University of Texas at Austin.

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LungCancer - Lung Cancer Genes Identified - Printout - TIME...

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