320Fall09Homework1 - b. If the bonding partner was changed,...

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Cell Biology (BIO 320), Fall 2009, Dr. Bushart Homework set #1 1. Dissolving solid urea in water is an endothermic reaction (+ΔH) yet it still occurs spontaneously at room temperature. a. How would heating the water help this process? b. Even at room temperature this process will occur. How can we explain this in terms of the free energy equation? Note that you should be able to answer this without looking up the specific details of how urea dissolves (which does help explain it too). 2. Imagine you have located one half of an attractive amino acid side chain pairing important for the function of a protein. a. If the amino acid you have identified is a member of the acidic side chain category, what two other side chain categories could its bonding partner possibly be from? Briefly explain your choices.
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Unformatted text preview: b. If the bonding partner was changed, which two categories would be most likely to disrupt the proteins function? Explain your choices. c. Why could a single change like in part b have an impact on the function of the protein? 3. Many drugs (both legal and otherwise) are functional because they can bind to the same site on a protein as the normal substrate or ligand does. What two general assumptions can we make about a drug of this type as compared to the natural substrate/ligand ? 4. What are the 4 folding-related fates of a newly synthesized protein? If the protein folds quickly, which outcome(s) are least likely? 5. How can chaperonin (hsp60) work with many different and unrelated proteins (i.e. why is it nonspecific in the proteins it can help to fold)?...
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