320Fall09Lecture2 - BIO 320 Cell Biology, Fall `09 Dr....

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BIO 320 Cell Biology, Fall ‘09 Dr. Thomas Bushart Lecture 2
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General themes in biology Hierarchies and emergent properties Structure and function are related Gene expression: I DNA RNA Proteins Energy, entropy, and stability ( G)
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Which tool? ? ?
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General themes in biology I The structure of X tells us something about its function I Similar structures likely have similar functions
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General themes in biology Gene expression (DNA RNA Protein) I DNA is information that is carried into action by proteins I Proteins can be viewed as “gene products” I The subset of genes expressed in a cell determines its identity
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General themes in biology Energy, entropy, and stability ( G) Cells exist in a state contrary to the natural order of the universe I Life could be defined by its counteraction to entropy “It’s not magic” I Why does water flow downhill? I How can fusion occur spontaneously in the sun but not here on earth? I Why does the same protein fold into the same confirmation (usually!)?
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Chemistry – the foundation Life is a collection of regulated chemical reactions I Understanding molecules informs us about cellular components Key points I Properties of molecules are determined by their arrangements of atoms I 4 non-covalent interactions organize molecules in cells I Energy resides in chemical bonds I Free energy (G) and equilibrium points can be used to describe reactions and determine their likelihood of occurrence I Cellular chemical reactions occur in sequences or pairs
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Biological molecules “Organic” simply refers to molecules containing carbon backbones X
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Chemical properties The reactivity and behavior of molecules can often be determined from functional groups of atoms along the carbon backbone
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(Inter)molecular interactions Covalent bonds and ionic bonds hold molecules together Other bonds determine the associations
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This note was uploaded on 09/15/2009 for the course BIO 320 taught by Professor Staff during the Fall '08 term at University of Texas at Austin.

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320Fall09Lecture2 - BIO 320 Cell Biology, Fall `09 Dr....

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