{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

320Fall09Lecture3 - BIO 320 Cell Biology Fall `09 Dr Thomas...

Info icon This preview shows pages 1–12. Sign up to view the full content.

View Full Document Right Arrow Icon
BIO 320 Cell Biology, Fall ‘09 Dr. Thomas Bushart Lecture 3
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Topics Protein folding and function Protein degradation I Proteasome I Ubiquitin tagging Misfolding and disease
Image of page 2
Self assembly Secondary tertiary folding can occur unaided I May require assistance from chaperones Individual subunits may interact in ways that lead to superstructures and highly ordered patterns I May need scaffolding or processing however
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Tomato bushy stint virus
Image of page 4
Subunit advantage Small amount of DNA can produce large structures Assembly and disassembly are controllable I Growth and shrinkage of cytoskeletal fibers Error correction I Badly made subunits simply won’t be used
Image of page 5

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Protein function Proteins work by binding I Shape I Intermolecular bonding
Image of page 6
Protein binding
Image of page 7

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Reactivity The arrangements of side chains may result in unexpected reactivities
Image of page 8
Proteins as enzymes Enzymes work by binding too I NOT like a glove Increase likelihood of the reaction I Bring reactants in close proximity I Alter electron distribution to favor reaction I Bind more favorably to the transition state
Image of page 9

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Reaction complexes Most enzymes are extremely specific in activity Enzymatic pathways utilize many enzymes to take small steps towards a final product Increase efficiency via spatial association
Image of page 10
Control of enzymatic activity At a basic level, how would you modulate the activity of a protein?
Image of page 11

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 12
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern