320Fall09Lecture4 - BIO 320 Cell Biology, Fall `09 Dr....

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BIO 320 Cell Biology, Fall ‘09 Dr. Thomas Bushart Lecture 4
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Topics Lipids and membranes Membrane-protein interaction
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Cell membranes Cell membranes are vitally important to the function of living cells Protects the cell as a whole Create microenvironments within the cell Specialized compartments Membrane environment itself Serve as scaffolds Increases opportunities for regulation Barriers for creating work (“hydroelectric dams”)
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Lipids Large and varied group Fatty acids Steroids
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Phospholipids Major component of cell membranes
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Specific membrane lipids
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Structure The amphipathic nature of phospholipids leads to autonomous organization in water
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Nonpolar molecules and water Both enthalpy (H) and entropy (S) values of free energy (G) favor clustering of hydrophobic molecules
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Structure and assembly Driven by lowest energy conformations
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Formation of compartments
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Liposomes
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Behavior of membanes Self assembling and healing Act as 2D fluids, individual phospholipids: Diffuse laterally rapidly Rotate easily Flex Rarely cross from one monolayer to the other (why?)
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Lipid-lipid-water interactions
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320Fall09Lecture4 - BIO 320 Cell Biology, Fall `09 Dr....

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