320Fall09Lecture5 - BIO 320 Cell Biology, Fall `09 Dr....

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BIO 320 Cell Biology, Fall ‘09 Dr. Thomas Bushart Lecture 5
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Topics Lipids and membranes Membrane-protein interaction
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Direct interactions α -helix common in eukaryotic proteins Hydrophobic residues exposed on the outside of the helix May have one or more membrane-spanning helices Single-pass or multipass
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Direct interactions Rolled β -sheet can from a β -barrel Receptors, enzymes, porins, channels Figure 10-26 Molecular Biology of the Cell (© Garland Science 2008)
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Helix vs. barrel α helix proteins are suitable for transmitting signals from one side of a membrane to the other Possible even with oliogmerized single-pass proteins β barrel protein structure tends to be too rigid Figure 11-10a Molecular Biology of the Cell (© Garland Science 2008)
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Lipid anchors Covalent linkages Limited to interactions on a single side Figure 10-20 Molecular Biology of the Cell (© Garland Science 2008)
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Cell-surface membrane proteins Disulfide bonds can form (non-reducing environment) Often modified by sugar groups (glycosylation/glycosyla ted) Figure 10-27 Molecular Biology of the Cell (© Garland Science 2008)
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Cell surface “Cell coat” or “glycocalyx” Figure 10-28a & b Molecular Biology of the Cell (© Garland Science 2008)
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Small amphiphilic (amphipathic) molecules with higher solubility in water than lipids Ionic or nonionic Cone-shaped Micelles or bilayers? Figure 10-29a
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320Fall09Lecture5 - BIO 320 Cell Biology, Fall `09 Dr....

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