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5 - LECTURE 5 ANNOUNCEMENTS LECTURE 5 1 QUIZ WED 9/9 MORE...

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LECTURE 5
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ANNOUNCEMENTS: FRIDAY'S LECTURE WHAT TO LEARN FROM AA SEQ WITHOUT 3D STRUCTURE : UNKNOWN PROTEIN-- LOOK FOR AA SEQ MATCH WITH KNOWN PROTEINS FIND EVOLUTIONARY RELATIONSHIPS TRY TO PREDICT 3D STRUCTURE(!) 3D STRUCTURE: X-RAY DIFFRACTION INTRO TODAY'S LECTURE WHAT ARE THE "RULES" FOR PROTEIN STRUCTURE? 4. REVIEW SESSION IN ROCKEFELLER 105 TODAY AT 5:30 PM AND TUE AT 3 PM IN 104. 3. OFFICE HOURS: TODAY: 2 - 4PM IN BIOTECH 202; TUESDAY: 8:30AM - 2:45PM IN BIOTECH 202 2. READING & PROBLEMS FOR THIS WEEK: AS IN LG FOR 9/7, 9/9, & 9/11 LECTURE 5 5. PyMOL INSTALLATION PROBLEM FOR SOME NEW LAPTOPS-- SEE OUR BLACKBOARD PyMOL SITE FOR DOWNLOAD FIX 6. COURSE POLICY FOR MAKE-UP MIDTERM (AND FINAL) EXAMS: WHEN THE DATE GETS CLOSE, PROF. MEETS WITH STUDENTS AND SETS THE DATE FOR THE MAKE-UP EXAM. 1. QUIZ WED 9/9. MORE INFO AT THE END OF TODAY'S LECTURE. 7. RE FRIDAY PM "DISCUSSION/INFO SESSIONS"-- IF YOU CANNOT ATTEND, PLEASE DO NOT ASK FOR NOTES OR TRANSCRIPT. JUST COME TO PROF'S THURS OFFICE HOURS.
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THE DIFFRACTION EXPERIMENT MEASURE DIFFRACTED X-RAY WAVES : DIRECTION INTENSITY X-RAY WAVELENGTH PHASE PROTEIN CRYSTAL X-RAY BEAM X-RAY WAVES DIFFRACTED BY PROTEIN CRYSTAL DETECTOR, e.g. CCD CAMERA OH NO! NO MATTER WHAT THE PHASE , THE SAME SPOT INTENSITY APPEARS ON THE DETECTOR: LOSE ALL PHASE INFO!
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