8 - LECTURE 8 ANNOUNCEMENTS 1. THIS WEEK: LG PROBLEMS 10 -...

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Unformatted text preview: LECTURE 8 ANNOUNCEMENTS 1. THIS WEEK: LG PROBLEMS 10 - 17; PyMOL ASSIGNMENT #3, PROTEIN FOLDS. 3. ANY STUDENT WHO HAS JUST ADDED THIS CLASS: MEET PROF RIGHT AFTER LECTURE TO DISCUSS HOW TO CATCH UP. FRIDAYS LECTURE: -SHEETS, TURNS, COLLAGEN STRUCTURE FOLDS, SUPERFAMILIES, FAMILIES: ONLY ABOUT 1000 DIFFERENT KINDS OF "FOLDS" TODAY'S LECTURE: MULTI-FOLD PROTEINS QUATERNARY STRUCTURE (IV) PROTEIN STABILITY 2. RE-GRADING POLICY: PUT QUIZ, WITH WRITTEN EXPLANATION/REQUEST FIRMLY ATTACHED , IN THE PURPLE RE-GRADE FOLDER ON THE TABLE AT THE FRONT OF THE LECTURE ROOM. NO ORAL ARGUMENTS!!! WRITTEN REQUESTS ONLY . 4. FOR ADMINISTRATIVE QUESTIONS, e.g. HOW TO ADD THIS COURSE, QUESTIONS ABOUT YOUR QUIZ SCORE, ETC: DO NOT ASK THE TA WHO RUNS THE VIRTUAL OFFICE HOURS. CONTACT THE PROF. THE HUMAN "KINOME" THE KINASE SUPERFAMILY PROTEINS IN THIS SUPERFAMILY CONTAIN SAME FOLD (STRUCTURAL DOMAIN); ALL 518 PROTEINS HAVE STRUCTURAL & EVOLUTIONARY RELATIONSHIP SOME FAMILIES WITHIN THE SUPERFAMILY: TK TYROSINE IS TARGET TKL TYROSINE KINASE-LIKE AGC INCLUDES PROTEIN KINASE A, PROTEIN KINASE G, AND PROTEIN KINASE C ALL CATALYZE PO 4 CHEM. MOD. OF TYR, OR THR, OR SER = PYRUVATE KINASE ALL LARGE PROTEINS: MORE THAN ONE FOLD BUT: A FOLD CAN FORM FROM NON-CONTINUOUS AA SEQUENCES PROTEINS HAVING MULTIPLE FOLDS WITHIN A SINGLE POLYPEPTIDE CHAIN AA 116-223 AA 1-115 AND 224-387 AA 388-530 CONSIDERING ALL LIFE FORMS : ALL THE TYPES OF INDIVIDUAL PROTEINS FOLDS ARE FOUND IN ALL LIFE FORMS! PROTEIN STRUCTURES THAT DIFFER AMONG LIFE FORMS ARE MADE FROM MULTIPLE FOLDS! 66kD CHAIN OF HIV REVERSE TRANSCRIPTASE A FOLD OFTEN IS A CONTINUOUS SEQUENCE OF AA REPEATED FOLDS CAN OCCUR (WITHIN A SINGLE POLYPEPTIDE CHAIN) COMPLEMENT CONTROL PROTEIN FOLD (C) IMMUNOGLOBULIN FOLD (I) FIBRONECTIN TYPE I FOLD (F1) GROWTH FACTOR FOLD (G) MANY PROTEINS: POLYPEPTIDE CHAIN HAS REPEATING RUNS OF SAME FOLD KRINGLE FOLD (K) AQUEOUS PROTEINS OR PROTEINS IN THE MEMBRANE BIOMEMBRANE FIBRONECTIN BLOOD CLOTTING FACTOR XII BLOOD CLOTTING FACTORS VII, IX, & X...
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This note was uploaded on 09/17/2009 for the course BIO G 101-104 taught by Professor Michealbradshaw during the Spring '09 term at Cornell University (Engineering School).

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8 - LECTURE 8 ANNOUNCEMENTS 1. THIS WEEK: LG PROBLEMS 10 -...

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