{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

8 - LECTURE 8 ANNOUNCEMENTS 1 THIS WEEK LG PROBLEMS 10 17...

Info icon This preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
LECTURE 8 ANNOUNCEMENTS 1. THIS WEEK: LG PROBLEMS 10 - 17; PyMOL ASSIGNMENT #3, PROTEIN FOLDS. 3. ANY STUDENT WHO HAS JUST ADDED THIS CLASS: MEET PROF RIGHT AFTER LECTURE TO DISCUSS HOW TO CATCH UP. FRIDAY’S LECTURE: β -SHEETS, TURNS, COLLAGEN STRUCTURE FOLDS, SUPERFAMILIES, FAMILIES: ONLY ABOUT 1000 DIFFERENT KINDS OF "FOLDS" TODAY'S LECTURE: MULTI-FOLD PROTEINS QUATERNARY STRUCTURE (IV) PROTEIN STABILITY 2. RE-GRADING POLICY: PUT QUIZ, WITH WRITTEN EXPLANATION/REQUEST FIRMLY ATTACHED , IN THE PURPLE RE-GRADE FOLDER ON THE TABLE AT THE FRONT OF THE LECTURE ROOM. NO ORAL ARGUMENTS!!! WRITTEN REQUESTS ONLY . 4. FOR ADMINISTRATIVE QUESTIONS, e.g. HOW TO ADD THIS COURSE, QUESTIONS ABOUT YOUR QUIZ SCORE, ETC: DO NOT ASK THE TA WHO RUNS THE VIRTUAL OFFICE HOURS. CONTACT THE PROF.
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
THE HUMAN "KINOME" THE KINASE SUPERFAMILY PROTEINS IN THIS SUPERFAMILY CONTAIN SAME FOLD (STRUCTURAL DOMAIN); ALL 518 PROTEINS HAVE STRUCTURAL & EVOLUTIONARY RELATIONSHIP SOME FAMILIES WITHIN THE SUPERFAMILY: TK TYROSINE IS TARGET TKL TYROSINE KINASE-LIKE AGC INCLUDES PROTEIN KINASE A, PROTEIN KINASE G, AND PROTEIN KINASE C ALL CATALYZE PO 4 CHEM. MOD. OF TYR, OR THR, OR SER =
Image of page 2
PYRUVATE KINASE ALL LARGE PROTEINS: MORE THAN ONE FOLD BUT: A FOLD CAN FORM FROM NON-CONTINUOUS AA SEQUENCES PROTEINS HAVING MULTIPLE FOLDS WITHIN A SINGLE POLYPEPTIDE CHAIN AA 116-223 AA 1-115 AND 224-387 AA 388-530 CONSIDERING ALL LIFE FORMS : ALL THE TYPES OF INDIVIDUAL PROTEINS FOLDS ARE FOUND IN ALL LIFE FORMS! PROTEIN STRUCTURES THAT DIFFER AMONG LIFE FORMS ARE MADE FROM MULTIPLE FOLDS! 66kD CHAIN OF HIV REVERSE TRANSCRIPTASE A FOLD OFTEN IS A CONTINUOUS SEQUENCE OF AA
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
REPEATED FOLDS CAN OCCUR (WITHIN A SINGLE POLYPEPTIDE CHAIN) COMPLEMENT CONTROL PROTEIN FOLD (C) IMMUNOGLOBULIN FOLD (I) FIBRONECTIN TYPE I FOLD (F1) GROWTH FACTOR FOLD (G) MANY PROTEINS: POLYPEPTIDE CHAIN HAS REPEATING RUNS OF SAME FOLD KRINGLE FOLD (K)
Image of page 4
AQUEOUS PROTEINS OR PROTEINS IN THE MEMBRANE BIOMEMBRANE FIBRONECTIN BLOOD CLOTTING FACTOR XII BLOOD CLOTTING FACTORS VII, IX, & X COMPLEMENT PROTEIN 2 N-CAM, A CELL ADHESION PROTEIN
Image of page 5

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern