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4 - ANNOUNCEMENTS LECTURE 4 1 QUIZ 1 WILL COVER THE FIRST 3...

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LECTURE 4 1. QUIZ 1 WILL COVER THE FIRST 3 LECTURES (AMINO ACIDS AND PEPTIDES), PLUS THE PyMOL TUTORIAL-- BUT NOT TODAY'S LECTURE! MORE INFO ON MONDAY. ANNOUNCEMENTS: 2. USE THE VOH! SEND MAIL TO [email protected] 3. ANY INTERESTED STUDENTS: “HOW TO FIND A LAB RESEARCH POSITION. WHAT ARE THEY LOOKING FOR?!", 3:25 - 4:15PM, TODAY IN COMSTOCK B108. WEDNESDAY’S LECTURE: IONIZABLE GROUPS THE HYDROPHOBIC EFFECT TODAY: 1. WHAT CAN WE SAY ABOUT PROTEINS WITHOUT KNOWING THE 3D STRUCTURE? PEPTIDES PROTEIN 3D STRUCTURE 2. FINDING THE 3D STRUCTURE INTRO TO MYOGLOBIN ISOZYMES X 5. INTERVIEWING AT MEDICAL & DENTAL SCHOOLS: TODAY 9/4 AT 12:20PM NORTH ROOM , WILLARD STRAIGHT 4. PyMOL REVIEWS: SUNDAY IN CARPENTER HALL COMPUTER LAB RED ROOM; TUESDAY IN 253 MALOTT: GETTING INTO MALOTT AFTER 4:30PM
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MYOGLOBIN BEHAVIOR PROPERTIES: SHOW O BINDING TWO WAYS: 2 153 AA, MW 17,000 IN MUSCLE CELLS; STORES O 2 [O 2 ] IN WATER ~ 0.3mM [MbO 2 ] IN CELLS ~ 100mM 1 AS AN EQUATION: Mb + O 2 MbO 2 DEOXY FORM OXY FORM 2 AS A GRAPH 1.0 0.5 - - UNITS OF PRESSURE: 1 TORR = 1mmHg = 133 Pascal TEXT USES kPa Hb Mb Mb RED BLOOD CELL
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HOW DOES O 2 BIND TO Mb? JARGON : NON-AA STRUCTURE COVALENTLY BOUND IN PROTEIN PROSTHETIC GROUP HOLOPROTEIN ENTIRE PROTEIN PLUS PROSTHETIC GROUP APOPROTEIN PROTEIN WITHOUT ITS PROSTHETIC GROUP e.g. "APOMYOGLOBIN" Fe 2+ IS USUALLY 6-COORDINATED 4 POSITIONS OCCUPIED BY HEME N 6 THEN: WHY NOT HAVE ONLY HEME FOR BINDING O 2 ?! HEME Fe-PROTOPORPHYRIN IX 1 2 3 4 6TH COORDINATION POSITION NOT OCCUPIED BY HEME OR BY Mb ATOMS: THIS IS WHERE O 2 BINDS 5TH POSITION IS N FROM HIS OF Mb 5
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