NS_115_term_paper - The Existence of Substantial...

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The Existence of Substantial Equivalence between MON corn and conventional products NS 115 Chong-Hyun (John) Kim TA: Harrison Moss 10/31/08 In the 21 st century, advanced technology flourishes in one’s life. The laptop, cell phone, and airplane are just a few of the great technologies of our time. Despite the thriving new technology, in 2005 UN scientists claim that one in six countries suffer from food shortage. In order to overcome this problem, scientists have developed genetically engineered (GE) crops, and the Monsanto Company introduced MON corn products which has had new genetic material inserted into the original corn plant to produce new traits. With new modified crops, harvest amount increases due to the high tolerance to herbicides and pests of the MON corn. However, controversy has arisen over safety issues. Consumers fear that GM foods pose a serious health risk to the general population. The controversy is: Is there a substantial equivalence in Monsanto Company’s corn products and non transgenic conventional corns? There are numerous articles that claim MON corn products do not cause adverse health effects due to the existence of substantial equivalence. Some studies have demonstrated safeness of MON corn products by conducting experiments feeding different types of diet to rats. They claimed that genetically modified corn was safe because the rats portrayed no irregularities in hematology, growth, and other parameters (Hammond et al. , 2006, Healy et al ., 2008). Also, other studies supported substantial equivalence between MON and conventional products by measuring general health, body weights, and compositional analyses in other species (George et al. , 2004, Taylor et al. , 2005 ). In 2006, Hammond et al. (2006) conducted a 90-day experiment with rats that followed OECD Good Laboratory Practice (GLP) guidelines at the Metabolism and Safety Evaluation
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organization to determine if there was a difference between MON 810 (transgenic with cry1Ab gene) and controlled grain (same background genetics as MON 810 but lacking the MON 810 coding sequence). In order to fulfill these objectives, a total of 400 rats were used in this study. They were approximately 6 weeks of age at the beginning of the study, and were divided randomly into 10 groups of 20 rats/sex/group. Two groups received controlled diet at levels of 11 % (weight of MON products/weight of entire diet, abbreviated as w/w troughout) and 33 %(w/w) and another two groups received MON 810 at levels of 11 % (w/w) and 33 %, (w/w) The rest of the groups received non transgenic corn grain from four different parts of the U.S. to approximate the normal range response to commercial non-transgenic corn grain. . The responses of rats fed a diet containing MON 810 were compared, based on weekly
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NS_115_term_paper - The Existence of Substantial...

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