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Lecture 33 Mutants_Viruses slides

Lecture 33 Mutants_Viruses slides - Part I Mutations 6th...

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Part I: Mutations 6 th : 280-281; 322-323 7 th : 286; 328-330 Part II: Viruses 6 th : 328-331; 333-335 (know Fig. 18.6) 7 th : 334-337; 339-341 (know Fig. 18.8)
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Mutation: uncorrected error in DNA sequence Mutations are heritable and MAY change the amino acid order in a protein. A mutation MAY change protein function or destroy function.
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Types of mutation 1. Point mutation : single base change 2. Insertion or deletion : one or more bases added or left out 3. Large-scale changes in chromosome structure ex.: inversion, duplication
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Substitution :replacement of 1 nucleotide by another (BOTH strands) Error! Correct Replication Next replication Parental DNA
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Silent mutation : a substitution that changes a codon to another that encodes the same amino acid ACA ; codes for threonine AC G ; also codes for threonine Silent mutation has NO EFFECT on amino acid sequence in protein
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Missense mutation : a point mutation that changes aa sequence CAC: histidine CA A : glutamine Missense mutation may have either a large or small effect on protein function - or no effect at all.
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Sickle cell disease : caused by a missense mutation in the β -globin gene.
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Nonsense mutation : a point mutation that creates a stop codon.
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