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Lecture 36 EukGenomes TO POST slides

Lecture 36 EukGenomes TO POST slides - Eukaryotic Genomes...

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Eukaryotic Genomes 6th ed: 356-361 7th ed; 374-381 Genome projects : Sequencing the entire genome of a species 1.Human 2.Model systems : mouse, Drosophila, yeasts, etc. 3. Crops : e.g., rice 4. Pathogens : protozoa, bacteria
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Species # of genes Geno size E. coli 4,288 0 Yeast 6,340 1 Drosophila 13,600 18 C. elegans (worm) 19,000 10 Arabidopsis (plant) 26,000 11 Mouse/human 30,000 2,9 Know these numbers
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Species # of genes Genome size Mbp E. coli 4,288 0.5 Yeast 6,340 12 Drosophila 13,600 180 C. elegans (worm) 19,000 100 Arabidopsis (plant) 26,000 119 Mouse/human 30,000 2,900 Genome sizes in Mbp = million base pairs
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Bacteria: >90% of genome codes for RNA and/or protein 98.5% of human genome doesn t code for protein or RNA. Most of genome is “junk” DNA with no known function.
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1.5% exons 24% introns & regula- tory sequences (promoters, control elements, etc) 15% unique non-coding DNA 59% repetitive DNA Human genome
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Fig. 19.4 (7th ed)
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Puffer fish ( Fugu ) has unusually short introns. Huntingtin: protein in nervous system in both humans & Fugu . mRNA, protein are same size in both species; (~3,500 amino acids) Intron size & number can vary greatly between species.
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Human huntingtin gene: 180 kb (kilo bases; thousand base pairs) Fugu gene: 24 kb Human gene: Fugu gene : (short lines are exons: intervening spaces are introns)
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Human, Fugu genes have same number & length of exons : human gene has longer introns .
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