Lecture 37 Structure CancerTO POST slides

Lecture 37 Structure CancerTO POST slides - Part I: Protein...

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Part I: Protein Structure 6th ed.: 313, 366 7th ed.: 319, 380 Part II: Cancer 6th ed.: 368-371 7th ed.: 370-373
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Protein Structure Proteins can consist of separate domains that fold independently and may be encoded by separate exons. domain
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Each domain can contain different secondary structure elements. (Only protein backbone is shown!) α -helix β sheet domain domain in protein
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Domains can have independent functions enzyme activity binds another protein
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Proteins are mix-and- match combinations of different domains Protein #1 Protein #2 The same domain is often found in different proteins.
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2 examples of domains 1. SH2 domain ; binds phospho-tyrosine (P-Tyr) 2. Helix-turn-helix (HTH) domain; binds DNA
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Src has 3 domains: SH3, SH2, and kinase Schematic:
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SH3 domain : binds other proteins SH2 domain : binds P-Tyr kinase domain : phosphorylates proteins
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The Src SH2 domain can bind a P-Tyr on another protein another protein P-Tyr Src
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SH2 domain part of another protein phospho- Tyr X-ray crystallography reveals details of binding
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SH2 domains are found in many proteins. They all bind P-Tyr.
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Relay proteins can bind receptor tyrosine kinases via SH2 domains SH2 domains (Chap. 11)
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sequence allow SH2 domains in different proteins to bind P-Tyr
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This note was uploaded on 09/19/2009 for the course BIO 202 taught by Professor Dean during the Spring '08 term at SUNY Stony Brook.

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Lecture 37 Structure CancerTO POST slides - Part I: Protein...

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