Chapter 10

Chapter 10 - Chapter 10 Gene Mutation: Origins and Repair...

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Chapter 10 Gene Mutation: Origins and Repair Processes Mutation changes one allelic form to another and is the ultimate source of genetic variation. Mutational variation underlies the study of genetics. Mutations are produced by mutagens or occur spontaneously. Point mutations include single base-pair substitutions, additions or deletions. Specialized forms of mutation include Some types of mutation can be repaired. expansion of trinucleotide repeats and insertion of transposable elements. Point mutation Single or few base pair changes Origin of point mutation induced by geneticist action of mutagen, an environmental agent that alters nucleotide sequence Spontaneous may be caused by errors in DNA replication provide “background rate” of mutation Types of point mutation Base substitution transition transversion Addition or deletion of nucleotide pairs (base-pair addition or deletion) also called indel mutations Molecular consequences (1) Synonymous mutation Missense mutation Nonsense mutation change codon for amino acid into translation termination (stop) codon Molecular consequences (2) Missense mutations differ in severity Nonsense mutation results in premature termination of translation, truncated polypeptides often are nonfunctional
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Chapter 10 - Chapter 10 Gene Mutation: Origins and Repair...

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