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ps4soln - Problem Set#4 BENG 434/ENAS 534 Biomaterials Due...

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Problem Set #4 BENG 434/ENAS 534 Biomaterials Due: Thursday, October 30th at the beginning of class 1. The family of PLA, PGA, and PLGA can be made using a number of synthetic methods, but the most common method is a ring opening polymerization using the appropriate ratios of glycolide and lactide. a. Since they are esters could they be made via esterification syntheses? If so, show the steps to make the polyester. They can be made by esterification. Direct esterification is probably the easiest to  show. b. Why might the ring opening polymerization be used? While the reaction will go, it won’t make very high mw polymer. The lactide and  glycolide will. 2. You want to synthesize a hydrogel because you have been reading that hydrogels have mechanical properties that are very similar to those of native tissues and they are very biocompatible. Hydrogels are water soluble polymers that are either chemically or physically crosslinked so that they form a swollen network in water. You know of several polymers (PEG, PVA among others which are water soluble. You decide to use PEG as the basis for your hydrogel. a. How is PEG typically synthesized? Draw the structures Ring opening polymerization. b. You have a block copolymer of PLA and PEG. The PEG blocks have Mn~10k g/mol and the PLGA blocks have Mn~1000 g/mol. Propose a means for synthesizing this polymer with PLA-PEG-PLA. c. List three techniques to characterize the polymer and provide a description of how those techniques work and what you learn from them.
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