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notes - 3.31.09

notes - 3.31.09 - Setting up a signaling gradient the role...

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Setting up a signaling gradient: the role of the  wingless  gene (Using Drosophila) Wingless  = secreted protein, cell-cell signaling molecule Wingless is involved in setting up a segments identity Cells know their positions within the body and differentiate accordingly - Anterior cells have hairs - Posterior cells do not have hair Cell-cell signaling can be influenced by distance between cells - Cells that are close become posterior - Farther away becomes anterior because they don’t get the wingless signal to be  posterior At beginning, there are four cells. Third cell secretes signal Wingless signaling specifies posterior cell fates in the ventral epidermis - Arm  gain of function mutant: all cells have anterior (hair) fate - Loss of function in wingless: all of the cells make hairs It is the concentration of  wingless  that determines cell fate
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