Pharm3 - NICOTIANA TABACUM "The Primary Shamanic...

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NICOTIANA TABACUM “The Primary Shamanic Plant” History of Tobacco o thousands of years o little smoking prior to Columbus (Old World, see Brugmansia pg12) o Native Americans showed Columbus smoking o early cash crop par excellence “Founder” Jean Nicot (1530-1600) o French ambassador who learnt of tobacco from a Portuguese botanist and brought it to France Structure Socio-Cultural Context of Usage o an aromatic, cleansing herb o holy smoke to bind friendships o holy smoke to seal covenants o healing medicinal properties Routes of Administration o smoking (inhalation) o oral-buccal (chewing tobacco) o intranasal insufflation (dry snuff) old style/Amazonia social o [oral-digestive o rectal] extremely dangerous routes Lethal Dose o LD-50 o legal dose that would kill 50% of the population o ~60mg in humans Nicotine Tolerance o tolerance develops to many of the toxic effects of nicotine (see below) o ex: nausea, increased heart rate, dizziness Main Effect in Nervous System o AGONIST at nicotinic acetylcholine receptors, which are found throughout the brain and body Acute (Short-Term) Effects o CNS stimulant and relaxant! o increased alertness and attentional focus o anxiolytic (anxiety-reducing) and grounding (connected to earth—solid/stable) o enhances REM sleep and dreaming o increased heart rate and blood pressure o increased metabolic rate (weight) o nausea, vomiting Toxic Effects of Tobacco Use on Health 14
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NICOTIANA TABACUM “The Primary Shamanic Plant” o Cardiovascular Effects of Nicotine ↑ heart rate, vaso constriction, blood pressure
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Pharm3 - NICOTIANA TABACUM "The Primary Shamanic...

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