Nitrile Hydrolysis Mechanisms

Nitrile Hydrolysis Mechanisms - 3 HO OH Acid Catalyzed...

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Nitrile Hydrolysis Mechanisms Basic Hydrolysis of Nitriles R N H 2 O/OH R OH O + NH 3 R N + OH N HO R N HO R + H 2 O N HO R H + HO N O R H R N H 2 O Amide R N H 2 O + OH R N H 2 O OH H 2 O R N H 2 HO OH R OH O + N H 3 R OH O + OH R O O + H 2 O H 2 O/H Work up R OH O H 2 O + OH Hydrolyze of Nitriles to Amides Hydrolyze of Amides to Carboxylic acids H 2 O R N H 3 HO OH + HO R N H
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Unformatted text preview: 3 HO OH Acid Catalyzed Hydrolysis of Nitriles N H N H OH 2 N H OH 2 N H OH 2 PS N H 2 OH N H 2 OH N H 2 OH OH 2 H 2 N OH OH 2 PS H 3 N OH OH- NH 3 O OH H- H O OH...
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This note was uploaded on 09/25/2009 for the course CH 223 taught by Professor Brown during the Spring '08 term at N.C. State.

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