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Immune074 - 10 Specific Defenses • Cell-mediated(T •...

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1 Components of the Lymphatic and immune System Rt.lymph.Duct Thoracic duct • Drain interstitial fluid • Transport lipids* & lipid soluble vitamins • Immune function • Primary (RBM, thymus) • Secondary (nodes, spleen, nodules)
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2 Lymphatic Capillaries Note: one-way flow…
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3 Note: order of flow blood--> interstitial --> lymph --> blood
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4 Structure of a Lymph Node
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5 -Associated Lymphoid Tissues • Nodules – Lymph tissue without capsule • Passageways – MALT – GALT
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6 Non-specific Immune Responses • First line: – Skin, mucuous membranes – Why? • Second line: – Interferon, transferrin, complement (30) – Natural Killer Cells – Neutrophils, Macrophages – Inflammatory Response Complement proteins are activated via 3 pathways: w/ or w/o Ab or lectin
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7 QuickTime ™  and a MPEG-4 Video decompressor are needed to see this picture. Macrophage and bacillus
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8 Inflammation
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9 Summary of Nonspecific Resistance What happens during viral infection? 1st line… 2nd line… 3rd line… What would happen to any pathogens Holly swallowed?
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Unformatted text preview: 10 Specific Defenses • Cell-mediated (T) • Humoral (B) 11 Specific Immunity • Ag-Ab • MHC • APC 12 Antigen Presenting Cell 13 14 Classes of Immunoglobulins 80% Secretions First responder Allergy B-cell activation Self-tolerance… 15 APCs: Macrophages, B-cells, dendritic cells MHC: Major Histocompatibility Complex 16 T-cell Activation: APC + Helper T + Interleukin 1 --> IL2 release --> Helper T, Cytotoxic T and B-cell activation --> More cells, Cellular response (cytotoxic), Humoral response (plasma cells and antibodies) MHC 17 Immunity 18 Secretion of Antibodies Immunity 19 Types of Immunity 20 Summary • Lymphatic system: fluid, circulation, structures • Non-specific Immune Responses: – 1st and 2nd Lines of Defense • Specific Immune Response: – 3rd Line: Cellular and Humoral Responses • Antigen-antibody complexes – Immunity • Disease: Stages of a viral infection...
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