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Unformatted text preview: BIS101 GENES AND GENE EXPRESSION Summer Session II MTWTh 9:00am-10:40am 180 Med Sci 1C Instructor: Dr. Deborah A. Kimbrell, Section of Molecular and Cellular Biology [email protected], 752-1116 Office Hours: T Th 11:00am-noon, 3114 Life Sciences, and by appointment Teaching Assistants: Jeffrey Myers [email protected] Office Hours: M 3:00-4:00pm, F 2:30pm-3:30pm, 3061 SLB Adam Ross [email protected] Office Hours: M noon-1:00pm, W 11:00am-noon, 3061 SLB General: The goal of this course is to provide an understanding of the fundamental concepts of genetics, both classical and molecular. This course will reinforce material you have received from previous courses, expand your knowledge into new areas, and enable you to proceed to more advanced courses with greater understanding. Analytical problem solving is integral to the study of genetics. Although there is much to memorize, the concepts of genetics cannot be mastered by simple memorization. You must actively solve genetics problems. In order to learn how to do this, work through the “Integration” and “Solved” problems at the end of each textbook chapter, then solve the additional problems that are assigned. The best way to do well in this class is to attend lecture, read the text, and solve the suggested problems. And, of course, ask questions. The TAs and I look forward to working with you as you learn genetics in this Genes and Gene Expression course. The website for this course can be accessed through SmartSite. Check this site daily for course information and other materials. Grading: Grades will be based on classroom participation (20 points), two midterms (110 points each), and a final exam (160 points) for a total of 400 points. The historical average for BIS101 classes has been a C/C+. Exams are given in class, and there will be no early, late or makeup exams. If an exam is missed and the absence is verified by a medical form from a treating physician, or other valid excuse with documentation, then the score will be calculated based on the other exams taken. If no valid documentation is received, a zero will be given for the missed midterm. Regrade requests for the midterm exams are filed in 156 Briggs Hall. To be considered, the petition must be filed no later than one week after the exam is returned and the exam must have been written in pen. The entire exam will be regraded upon filing a petition. Please file a regrade petition in the case of errors in adding up points earned. These exams can be in pen or pencil. According to University policy, final exams cannot be regraded. INTRODUCTION: MENDEL TO GENOMICS
I. Course introduction II. DNA molecules encode biological information III. Central dogma: DNA-> RNA -> protein IV. DNA and evolution of life forms V. Model organisms VI. Forward and reverse genetics VII. Humans and genomics research • • • • Organism
Human (Homo sapiens) Laboratory mouse (M. musculus) Mustard weed (A. thaliana) Roundworm (C. elegans) Fruit fly (D. melanogaster) Yeast (S. cerevisiae) Bacterium (E. coli) Human immunodeficiency virus (HIV) Genome Size (Bases)
3 billion 2.6 billion 100 million 97 million 137 million 12.1 million 4.6 million 9700 Estimated Genes
30,000 30,000 27,000 19,500 13,000 6,000 3,200 9 • • • • Molecular Medicine
• improve diagnosis of disease • detect genetic predispositions to disease • create drugs based on molecular information • use gene therapy and control systems as drugs • design “custom drugs” (pharmacogenomics) based on individual genetic profiles Microbial Genomics
• rapidly detect and treat pathogens (disease-causing microbes) in clinical practice • develop new energy sources (biofuels) • monitor environments to detect pollutants • protect citizenry from biological and chemical warfare • clean up toxic waste safely and efficiently
U.S. Department of Energy Genome Programs, Genomics and Its Impact on Science and Society, 2003 Risk Assessment
• evaluate the health risks faced by individuals who may be exposed to radiation (including low levels in industrial areas) and to cancer-causing chemicals and toxins Bioarchaeology, Anthropology, Evolution, and Human Migration
• study evolution through germline mutations in lineages • study migration of different population groups based on maternal inheritance • study mutations on the Y chromosome to trace lineage and migration of males • compare breakpoints in the evolution of mutations with ages of populations and historical events U.S. Department of Energy Genome Programs, Genomics and Its Impact on Science and Society, 2003 Agriculture, Livestock Breeding, and Bioprocessing
• grow disease-, insect-, and drought-resistant crops • breed healthier, more productive, disease-resistant farm animals • grow more nutritious produce • develop biopesticides • incorporate edible vaccines incorporated into food products • develop new environmental cleanup uses for plants like tobacco U.S. Department of Energy Genome Programs, Genomics and Its Impact on Science and Society, 2003 Dissection of genomes gene-bygene unravels the complexity of biological systems. The challenge for modern biology lies in understanding how the multitude of networks of genes and higher level systems interact to produce complex systems. ...
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This note was uploaded on 09/26/2009 for the course BIS 98659 taught by Professor Kimbrell during the Summer '09 term at UC Davis.
- Summer '09