Lecture 15 Guide

Lecture 15 Guide - Indel mutations result in frameshifts...

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Unformatted text preview: Indel mutations result in frameshifts Slipped mispairing causes repeat expansion Oxygen radicals can damage DNA Alternative pairings for 5-bromouracil (5-BU) Intercalating agents UV-light-generated photoproducts Consequences of point mutations within genes --- coding region Consequences of point mutations on gene products Point mutations can alter mRNA splicing The Ames test reveals mutagenic compounds Ames test of aflatoxin B1 mutagenicity A photodimer may be reversed by direct repair Minor base damage is detected and repaired by base-excision repair Two pathways for nucleotide-excision repair Mismatch repair corrects replicative errors --- model for mismatch repair in E. coli Translesion synthesis bypasses lesions at stalled replication forks Error-prone nonhomologous end joining repairs double-strand breaks Error-free repair of double-strand breaks by SDSA Crossing over during meiosis Double-strand breaks initiate meiotic recombination The early crossover decision model Gene conversion results in aberrant segration ratios ...
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