Questions and Answers Part 5 9 2

Questions and Answers Part 5 9 2 - 1. Nearly half the human...

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1. Nearly half the human genome consists of DNA that can be classified by sequence as “transposable elements,” yet many of these sequences are incapable of moving throughout the genome. This is best attributed to: (a) Lack of any transposon sequence encoding reverse transcriptase in the human genome. (b) Accumulation of mutations in transposon-derived sequences that has rendered the sequences no longer functional. (c) Now that modern humans have evolved, the genome will no longer tolerate change. (d) All human transposons originated as retroviruses, but without the original parent virus present, no transposon movement can occur. Answer: B 2. What is the most reasonable explanation for the observation that transposons in the human genome are more often found in nongenic sequences such as the centromere than in genic sequences? (a) Insertion into nongenic DNA is less likely to have a negative phenotypic effect than insertion into genic DNA. (b) The AT-rich nature of centromere and other nongenic sequences makes it easier for transposon insertion. (c) Reverse transcriptase promotes integration into nongenic DNA preferentially. (d) Genic DNA is protected from transposon insertion by all the transcription factors bound to the region. Answer: A
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Questions and Answers Part 5 9 2 - 1. Nearly half the human...

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