BIOL 200 - Lecture 08

BIOL 200 - Lecture 08 - Unit 8 Eye Skin Antimicrobials Wide...

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1 Unit 8 Wide Angle
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2 Narrow Angle Three major types of glaucoma and basic treatment: • Congenital Glaucoma ± surgery required • Primary Glaucoma – Narrow angle (also called acute congestive) ± cause: poor drainage because of position of iris • drug treatment chiefly pupil constrictors • eventually may be treated with surgery – Wide angle (or chronic simple) ± cause: poor drainage most probably due to abnormal blood vessel permeability • most common type of glaucoma • requires permanent drug therapy • pupil constriction often helps drainage • use drugs to decrease aqueous humor formation • Secondary Glaucoma ± develops secondary to other eye disease (i.e. inflammation) or cataract surgery – treat with corticosteroid or antiinfective and glaucoma usually disappears Classification of Antibiotics • Clinical use depends on their abilitiy to selectively kill or inhibit replication of invading organisms without significant damage to host cells. • Designed to interfere with a phase of cell physiology that is unique to the pathogen. • Classified according to MOA, chemical structure, and spectrum of activity against particular organisms.
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3 Bacteriostatic vs. Bactericidal • Bacteriostatic : – Stop microbial – Limits spread of infection – Relies on host’s immune system to naturally eliminate pathogens • Bactericidal – Kills bacteria – Immediately decreases number of viable pathogens in host – Preferred for patients with compromised immunity – Also life threatening infections Antimicrobial Spectrum • The spectrum of activity refers to the range of pathogens that can be effected by an individual drug. • Drugs with a narrow spectrum can act on a single organism or few groups of organisms. ( penicillins) • Broad spectum agents are effective against a wide variety of pathogens. ( fluoroquinolones ) • Extended-spectrum antibiotics have an intermediate range of activity and target gram+ & some gram- organisms. (cephlosporins) – Worry about altering nonpathogenic bacterial flora Mechanisms of Resistance • Bacterial resistance develops if growth is not
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This note was uploaded on 09/26/2009 for the course BIOL 200 taught by Professor Egan during the Summer '09 term at Golden West College.

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BIOL 200 - Lecture 08 - Unit 8 Eye Skin Antimicrobials Wide...

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