BIOL 200 - Lecture 08 - Unit 8 Eye Skin Antimicrobials Wide...

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1 Unit 8 Eye, Skin & Antimicrobials Wide Angle
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2 Narrow Angle Three major types of glaucoma and basic treatment: Congenital Glaucoma ± surgery required Primary Glaucoma Narrow angle (also called acute congestive) ± cause: poor drainage because of position of iris drug treatment chiefly pupil constrictors eventually may be treated with surgery Wide angle (or chronic simple) ± cause: poor drainage most probably due to abnormal blood vessel permeability most common type of glaucoma requires permanent drug therapy pupil constriction often helps drainage use drugs to decrease aqueous humor formation Secondary Glaucoma ± develops secondary to other eye disease (i.e. inflammation) or cataract surgery treat with corticosteroid or antiinfective and glaucoma usually disappears Classification of Antibiotics Clinical use depends on their abilitiy to selectively kill or inhibit replication of invading organisms without significant damage to host cells. Designed to interfere with a phase of cell physiology that is unique to the pathogen. Classified according to MOA, chemical structure, and spectrum of activity against particular organisms.
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3 Bacteriostatic vs. Bactericidal • Bacteriostatic : Stop microbial growth & replication Limits spread of infection Relies on host’s immune system to naturally eliminate pathogens • Bactericidal Kills bacteria – Immediately decreases number of viable pathogens in host Preferred for patients with compromised immunity Also life threatening infections Antimicrobial Spectrum The spectrum of activity refers to the range of pathogens that can be effected by an individual drug.