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Antigen and Immunogenicity

Antigen and Immunogenicity - ANTIGEN IMMUNOGENICITY...

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ANTIGEN & ANTIGEN & IMMUNOGENICITY IMMUNOGENICITY 1. Factors That Influence Immunogenicity 2. Epitopes
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9/21/2009 Antigen & Immunogenicity 2 Antigen & Immunogenicity Antigen & Immunogenicity An immune response is characterized by the production of proteins (called immunoglobulins or antibodies) and specifically reactive lymphocytes (T cells) when a host encounters a foreign macromolecules or cell. The inducing substances are called antigens , i.e., anti body gen erators), or immunogens. Immunogenicity is the inherent ability of a substance to induce a specific immune response: Immunogen + B cells Effector B cells (Plasma cells) + Memory B cell Immunogen + T cells Effector T cells (Helper T Cell/Cytotoxic T Cell) + Memory B cell Antigenicity is the ability to combine specifically with the final products of the above responses, i.e., antibodies and/or cell-surface receptors. Haptens are molecules that are not immunogenic by themselves, but can react with specific antibodies. Haptens are usually small molecules, but some high-molecular-weight nucleic acids are haptens as well.
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