Addiction Summer 2007

Addiction Summer 2007 - Drug Reward and Addiction 2006...

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Drug Reward and Addiction 2006 Darryl Neill
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Current Definition of Addiction 1. Chronic use of a substance 2. In the face of negative consequences.
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Phases of Drug Addiction Phase One: Encountering the drug and deciding how much you like it. Phase Two: Taking the drug again…and again. Phase Three: Chronic, compulsive use.
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Major Questions in Current Addiction Research 1. How do drugs of abuse act in the nervous system? What is the neural basis of the “high?” 2. What accounts for individual differences in reaction to a drug of abuse? Is there an “addictive personality?” 3. Why is it so difficult to quit drug abuse? Why is relapse so prevalent?
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Phase I: How much do you like the drug? First, we must know the brain bases of the drug reward.
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Intravenous Self-Administration (IVSA) in Rats
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Conditioned Place Preference (CPP)
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Brain Circuits Acted Upon by Drugs of Abuse
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Phase 2: A Possible Change in the Brain’s Response to the Drug: “Sensitization”
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Problem of Relapse
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Addiction Summer 2007 - Drug Reward and Addiction 2006...

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